Postdoctoral Scholar, Cell and Genetic Medicine

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn

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** Job Function:*
* Career Programs

** Job Sub*
* ** Function:*
* Post Doc - Drug Discovery & Pre-Clinical/Clinical Development

** Job Category:*
* Career Program

** All Job Posting Locations:*
* San Diego, California, United States of America

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* Job Description:

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* About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

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Johnson & Johnson Innovative Medicine R&D is recruiting for a Postdoctoral Scholar, Cell and Genetic Medicine located in San Diego, CA.

Fixed-Term role - Ineligibility for severance

The Postdoctoral Scholar will focus on advancing Lipid Nanoparticle (LNP)-based nucleic acid delivery and genome engineering approaches for next-generation cell and gene therapy applications. This individual will design and execute in vitro assays, evaluate delivery efficiency and nuclear delivery in relevant cellular models, and contribute to LNP formulation and targeted delivery strategies.  Collaborate across cross-functional teams to advance research spanning molecular delivery and genome engineering in a dynamic, multidisciplinary research environment.

Principal Responsibilities:

+ Independently design, execute, and optimize in vitro assays to assess LNP-mediated nucleic acid tolerability, delivery and nuclear localization in relevant cellular models, including primary immune cells.

+ Support the molecular design and evaluation of approaches to improve nuclear uptake, leveraging expertise in molecular and cellular biology as well as nucleic acid biochemistry or related fields.

+ Analyze and interpret experimental data with scientific rigor, ensuring reproducibility and data quality.

+ Contribute to lipid nanoparticle (LNP) formulation and optimization efforts, including formulation workflows and analytical characterization.

+ Actively advance and apply LNP and analytical techniques within the project scope.

+ Support development of bioconjugation strategies and related analytical methods for targeted LNP delivery applications.

+ Partner with cross-functional teams to advance project goals.

+ Develop a scientific and technical skillset through project assignments, advanced training, conferences, internal meetings, and symposia in relevant areas.

+ Develop in-depth knowledge of the organization's drug discovery and preclinical/clinical development processes, programs, policies, and scientific approaches within a multidisciplinary pharmaceutical research environment.

This postdoctoral research position will require full-time, on-site work in a BSL-2 laboratory environment.  It is designed to provide advanced scientific training, exposure to drug discovery and pre-clinical development processes, and opportunities to contribute to innovative research in non-viral nucleic acid delivery and genome engineering for cell and gene therapy applications.

Qualifications:

+ A minimum of a Ph.D. in Molecular Biology, Cell Biology, Chemical Biology, Biochemistry, Bioengineering, Biophysics, Pharmaceutical Sciences, or related discipline is required.

+ Strong foundation in molecular biology and…