Research Assistant II - Briney Lab

Position Title

Research Assistant II

The Briney Lab is seeking a Research Assistant II to join us in the Department of Immunology and Microbiology at Scripps Research. We use advanced single cell multi-omics techniques and sophisticated computational tools to deeply explore the antibody response to emerging infectious diseases. We are looking for a highly motivated individual who will contribute to antibody discovery projects against a variety of viral targets, including Lassa, Ebola, HIV, SARS‑CoV‑2, influenza, astrovirus, and others.

The antibodies we discover have potential use as therapeutics or as templates for rational vaccine development. Primary responsibilities include performing single cell sequencing experiments and functional characterization of monoclonal antibodies (binding, neutralization, etc.). The ideal candidate can work independently, leading antibody discovery campaigns from initial B cell isolation through detailed functional evaluation of recombinantly expressed antibodies. We are members of several large national/international consortia, so excellent communication skills and the ability to work effectively in a collaborative environment are required.

The Briney Lab actively integrates AI and computational tools into our research and we encourage all lab members to use them responsibly. We are especially interested in candidates who are curious or already comfortable using AI assisted tools in a research environment.

• Generate single cell multi‑omics sequencing libraries using the 10x Genomics Chromium platform
• Perform next‑generation sequencing experiments using Illumina and Oxford Nanopore systems
• Cloning, recombinant expression, and purification of monoclonal antibodies
• Production of a variety of viral antigens used for antibody isolation and characterization
• Antibody binding assessment by ELISA, BLI, and/or SPR
• Pseudovirus‑based neutralization assays
• General lab responsibilities, including maintaining inventory of commonly used reagents/supplies and routine equipment maintenance
• Present work at lab meetings and contribute to peer‑reviewed publications
• Work closely with other Briney Lab members and our collaborators
• Work under minimal supervision. Independently conduct a wide variety of standard laboratory techniques/procedures while using judgement when necessary to adapt standard methods and techniques. Receive instructions on specific assignment objectives, complex features, and possible solutions.

• Requires a bachelor’s degree in a relevant scientific discipline or an equivalent combination of education, training and/or experience from which comparable knowledge, skill and abilities have been attained.
• Requires 3‑5 years’ experience. Candidates possessing a master’s degree, 2+ years’ experience required.
• Must have substantial expertise in recombinant protein production and purification.
• Experience with antibody binding assays and pseudovirus neutralization assays is highly preferred.
• Experience with single cell techniques (specifically the 10x Genomics platform) and next‑generation sequencing is preferred, but is not required.
• Python programming experience would be a plus, but is not required.

• This position works in a laboratory or vivarium environment.
• Details of established essential functions for this position will be addressed/discussed during the interview process.

The expected hiring range for this position is $70,304 to $77,000 per year, commensurate with experience. Consideration will be given to experience that exceeds the listed requirements.

• Employer Contributed Retirement Plan – Depending on eligibility, employees receive an employer contributed retirement plan (no employee contribution required) and the option to contribute to a 403(b) (which is similar to a 401(k) using your own pre or post‑tax dollars)
• Full Suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more Access to Flexible Spending Accounts (Medical/Dependent Care)
• Competitive vacation and sick leave policies
• Fr…