Principal Scientist, Early Pipeline Development

Principal Scientist I/II – Onsite, San Diego, CA. Responsible for developing downstream purification processes for next‑generation AAV gene therapy and early‑stage process development. Lead a 3‑5 person downstream process team.

• Lead and manage a 3‑5 person downstream process team; provide technical support, training, and SME knowledge to direct reports.
• Coordinate activities with associates across upstream process and analytical teams.
• Develop strategies in collaboration with Disease Areas and partner with various line functions to support early drug discovery from target selection and validation through lead compound selection and develop ability assessment.
• Serve as a subject matter expert to transfer manufacturing process knowledge to the Technical Research & Development team and advance pipeline programs into clinical phases.
• Lead effort and work collaboratively with Technical Research & Development to develop innovative and cost‑effective downstream processes for next‑generation AAV.
• Manage multiple project workflow to ensure timely delivery.
• Prepare written reports conforming to defined documentation practices, including electronic lab notebook.
• Other related duties as assigned.

• PhD in bioprocessing, biochemical engineering, gene therapy or a related field with 3+ years of relevant process development experience in the biopharmaceutical environment.
• Experience in people management.
• Knowledge of downstream purification processes including affinity and ion‑exchange chromatography with hands‑on experience with AKTA purification systems.
• Technical proficiency, creativity, and independent thought.
• Effective communication skills to convey scientific concepts to research scientists and cross‑functional collaborators.
• Strong organization and problem‑solving skills with attention to detail.
• Ability to work in a fast‑paced and matrix environment.

• Experience in AAV gene therapy.
• Experience with viral gene therapy.

Salary range:
Principal Scientist I – $108,500 to $201,500 per year;
Principal Scientist II – $119,700 to $222,300 per year. Final salary offered is determined by relevant skills and experience, reviewed periodically, and may be adjusted based on company and market factors. Compensation includes a performance‑based cash incentive and potential annual equity awards.

US‑based eligible employees receive a comprehensive benefits package including health, life, and disability benefits, a 401(k) with company contribution and match, and other benefits. They also receive a generous time‑off package including vacation, personal days, holidays, and other leaves.