Scientist II, Analytical Development; Oligonucleotide

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Full Time San Diego, CA, US

30+ days ago Requisition

Salary Range: $ To $ Annually

Profoundly Improve People’s lives by Revolutionizing the Delivery of RNA Therapeutics

At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people’s lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies.

If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients.

Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs™). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD).

Avidity is broadening the reach of AOCs with its advancing and expanding pipeline, including programs in cardiology and immunology through internal discovery efforts and key partnerships. Avidity is headquartered in San Diego, CA. For more information about our AOC platform, clinical development pipeline, and people, please visit  and engage with us on Linked In and X.

We are seeking a Scientist II to join the Analytical Development group who is experienced and committed to developing and running oligonucleotide methods to support our AOC research and clinical programs. This is a hands‑on position with responsibilities that require daily lab work, data analysis, and interpretation of data that will be shared with cross‑functional teams and key stakeholders. The position will report to the Director of Analytical Development and be a part of Avidity's growing CMC/Technical Operations team.

• Strong knowledge of nucleic acids chemistry and oligonucleotide analytical separation techniques. Including IP‑RP‑UPLC, AEX, and HILIC.
• Experience with mass spectrometry techniques to characterize oligonucleotides (Orbitrap, QQQ, Single Quad).
• Independently develops and qualifies analytical methods (IP‑RP‑UPLC denaturing, non‑denaturing, sequencing, identity, residual solvent, and assay content) to support oligonucleotide release and stability testing.
• Works closely with external CROs to advance method development, qualification, transfer, and validation for Avidity programs.
• Provides a detailed review of protocols, reports, and raw data for analytical method qualification/validation, release testing, and reference materials qualification.
• Implements novel analytical techniques to overcome analytical challenges in the characterization of oligonucleotides.
• Documents experiments in electronic notebooks and writes technical reports summarizing findings.
• Authors or reviews relevant regulatory submissions.
• Provides updates and presents data proactively and regularly in group and CMC meetings.
• Ensures adherence to applicable regulations, including FDA, EMA, ICH, GMP, and internal Avidity policies.
• Provides leadership and mentorship to laboratory research associates.
• Contributes to the company's core values (agile, visionary, integrated, and diverse).

• Minimum PhD in chemistry, biology, biochemistry, pharmaceutical sciences, with 1‑3 years of pharmaceutical industry experience or BS/MS degree with 8‑10 years of industry experience.
• Deep knowledge of oligonucleotide analytical separation techniques.
• Understanding of method qualification/validation and transfer to QC. Experience in…