Principal Scientist, Biophysicist

We are seeking a highly motivated and experienced Principal Scientist / Biophysicist to join our dynamic team in La Jolla, CA. You will work on-site full-time and bring deep expertise in biophysical assay development and high-throughput screening. If you have a passion for advancing scientific discovery and thrive in a fast-paced, collaborative, and cross-disciplinary environment, we encourage you to apply.

• Design, develop, and optimize biophysical assays (e.g., SPR, BLI) for characterization of small molecules.
• Execute routine assays for defining structure-activity relationships.
• Implement and manage automation solutions to enhance assay throughput and data quality.
• Collaborate with cross-functional teams to integrate new technologies and workflows into ongoing research projects.
• Analyze, interpret, and present scientific data to internal and external stakeholders.
• Maintain detailed laboratory records, contribute to the preparation of research reports and publications, and represent the team through internal presentations.

• Ph.D. (post-doc preferred), in a relevant scientific discipline (e.g., Biophysics, Biochemistry, Bioengineering, or a related field), with 2+ years of industrial experience in drug discovery.
• Deep expertise in designing, validating, executing, and troubleshooting biophysical assays.
• Ability to manage multiple projects independently and adapt to evolving research priorities.
• Ability to innovate, keep up with the expanding field, recommend and bring in new technologies.
• Strong analytical, troubleshooting, and problem-solving skills.
• Excellent communication and teamwork abilities.

• Experience in integrating novel or emerging technologies into high-throughput screening workflows.
• Familiarity with data analysis software and electronic laboratory management systems.
• Hands‑on experience with laboratory automation platforms and liquid handling systems.

The salary for this position is expected to range between $108,500 and $201,500 per year for Principal Scientist I, and between $119,700 and $222,300 per year for Principal Scientist II. The final salary offered is determined based on factors such as relevant skills and experience, and will be reviewed periodically upon joining Novartis. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time‑off package including vacation, personal days, holidays, and other leaves. To learn more about our culture, rewards, and benefits, .