Scientist II, Biomarkers

Job Title: Scientist II, Biomarkers

Company: SRT Therapeutics

Location: San Diego, CA. 100% on-site

Reports To: Biomarkers Lead

Salary range: $92,000 - $153,000

SRT Therapeutics is a San Diego-based biotech company established in 2024 by the founders of Prometheus Biosciences, Steph Targan, MD (Cedars Sinai), Janine Bilsborough, Ph.D. (Cedars Sinai), the scientific team that discovered Tulisokibart (MK7240) and the role of TL1A in IBD and Scott Glenn and Lauren Otsuki, the drug development team that took Tulisokibart (MK7240) from academia into the clinic. Building on the demonstrated success of the precision medicine approach in IBD with Tulisokibart, SRT Therapeutics will expand this approach by targeting key pathways that not only modulate inflammatory pathways, but also promote tissue healing in IBD.

This strategy will move SRT Therapeutics beyond the current empirical treatment model to realize the goal of enhancing both outcomes and the quality of care for our patients.

We are seeking a highly motivated and technically proficient Scientist II to join our Biomarkers team. The ideal candidate will have hands‑on expertise in designing, executing, and analyzing complex experiments relevant to immunology, and is driven to generate high‑quality mechanistic data. This role requires a proactive, solutions‑oriented approach, the ability to adapt to evolving priorities in a fast‑paced environment.

• Design, develop, and validate primary cell functional assays to assess mechanism of action.
• Develop biomarker assays to support target engagement, receptor occupancy, and pharmacodynamic studies.
• Perform high‑quality data analysis, interpretation, and rigorous documentation of experimental results in ELNs and technical reports.
• Collaborate closely with research groups in a matrixed setting to ensure priorities are met.

• PhD desired in Immunology, Cell Biology, or a closely related field.
• 3 – 5 years industry or mixed academic with a minimum of 1 year industry experience in immunology, drug discovery, or translational research.
• Hands‑on expertise in immunology lab techniques, including demonstrated ability to isolate, culture, and characterize primary human immune cells and tissue in functional assays.
• Expertise in advanced multi‑color flow cytometry (panel design, optimization, acquisition, and analysis with Flow Jo).
• Experience developing and running immunoassays (ELISA, MSD).
• Experience in the development or technical execution of assays for translational biomarkers (pharmacodynamic, target engagement, receptor occupancy assays).
• Proven ability to work efficiently in a laboratory setting, manage time effectively, and troubleshoot complex technical issues.
• Strong communication skills, with the ability to clearly present laboratory findings and proposed next steps to a scientific team.