Research Assistant II - Pharmacology

About Us

Cali ‑Skaggs Institute for Innovative Medicines was founded on the principle that the creation of new medicines can be accelerated by pairing world‑class biomedical research with state‑of‑the‑art drug discovery and development capabilities. Cali ‑Skaggs is a division of Scripps Research, a first‑of‑its‑kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Scripps Research is ranked the most influential institution in the world for its impact on innovation.

Our educational and training programs mold talented and committed students and postdocs into leading‑edge scientists. Leveraging the unique scientific environment of Scripps Research, impacting translational sciences, Cali ‑Skaggs has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while reinvesting in further innovative research. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing.

Cali ‑Skaggs’ drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected tropical diseases, as well as age‑related and degenerative diseases. If you have a passion for making a difference, this could be your opportunity to join our transformative team.

Research Assistant II

The Cali  Bioanalytical team is seeking a highly motivated individual to support pharmacology in our drug discovery efforts. Under this role, the ideal candidate will work to develop LC‑MS assays for novel compounds to support key ADME and pharmacokinetic assays and assist in developing new ADME assays to increase internal bioanalytical capabilities. The individual would work in support of multiple drug discovery programs that encompass multiple modalities such as small molecule, peptide, protein, and antibody therapeutics.

• Prepare biological samples from various matrices, including tissue homogenization, and support bioanalytical method development.
• Develop and optimize LC‑MS methods for the quantitative analysis of new molecular entities (NMEs) in support of drug discovery programs.
• Perform routine maintenance, troubleshooting, and optimization of LC‑MS instrumentation and analytical methods.
• Analyze experimental data and maintain accurate, complete laboratory notebook documentation.
• Manage laboratory databases and perform routine laboratory maintenance to ensure efficient operations.
• Prepare bioanalytical reports and present experimental results to cross‑functional research teams.
• Conduct quality control (QC) reviews of pharmacokinetic (PK) and ADME reports generated by external contract research organizations (CROs).
• Demonstrate strong attention to detail, effective troubleshooting skills, and the flexibility to thrive in a fast‑paced research environment.
• Additional essential functions and responsibilities for this position will be discussed during the interview process.

• Requires a bachelor's degree in chemistry, biochemistry or a relevant scientific discipline or an equivalent combination of education, training and/or experience from which comparable knowledge, skill and abilities have been attained.
• Requires 3‑5 years' experience. Candidates possessing a master's degree, 2+ years' experience required.
• Experience in biochemistry, pharmacology, 1-3 years of experience in a bioanalytical laboratory.
• Strong operational expertise in LC/MS, with familiarity with SCIEX mass spectrometry instrumentation preferred.
• Hands‑on experience developing LC‑MS/MS assays for the quantitation of small molecules and the identification of metabolites in a variety of biological matrices.
• Experienced in sample preparation techniques, including solid‑phase extraction (SPE) and liquid‑liquid extraction (LLE).
• Demonstrated strong attention to detail, critical thinking, and effective troubleshooting abilities.
• Proven ability to manage multiple priorities and successfully execute multiple…