Director, Translational Pharmacology

Position Summary

Travere Therapeutics is seeking an experienced and strategic scientist to join our Research and Nonclinical Development organization as Director, Translational Pharmacology. The role serves as a key scientific contributor to external evaluation of business development opportunities, focusing on therapeutic rationale, disease biology, mechanism of action, translational strategy, pharmacology data, biomarker approaches, and development feasibility for potential external assets and collaborations in the rare disease space.

San Diego, USA – Remote collaboration, but the position requires face‑to‑face onsite work in San Diego; 100% remote is not expected.

Serve as a preclinical biology lead or key scientific contributor for evaluation of business development opportunities ranging from small‑molecule to biologics at all stages of development, including external assets, platform‑based technologies, and research‑based collaborations.

Assess scientific rationale, mechanism of action, disease biology, pharmacology and toxicology data, translational relevance and therapeutic safety window, biomarker strategy, and development feasibility for potential opportunities.

Review and interpret nonclinical and translational data alongside clinical, regulatory, and competitive information to identify strengths, risks, gaps, and key value drivers.

Partner with Business Development and cross‑functional diligence teams to develop scientific assessment reports, diligence questions, risk summaries, and recommendations.

Identify critical experiments, analyses, or expert input needed to reduce scientific uncertainty for potential opportunities.

Support evaluation of strategic fit with Travere’s portfolio, therapeutic areas of interest, rare disease focus, and translational development capabilities.

Provide translational pharmacology expertise across preclinical and clinical‐stage opportunities, including interpretation of in vitro, in vivo, ex vivo, biomarker, pharmacodynamic, and clinical pharmacology data.

Evaluate whether available pharmacology and translational data support proposed mechanisms of action, target engagement, dose rationale, patient selection, and clinical development strategy.

Integrate mechanistic biology, pharmacology, biomarker, and clinical observations to assess therapeutic potential and development risk.

Stay abreast of industry trends, emerging technologies, advances in disease biology and therapeutic targets, and competitive activities to inform search strategies and evaluations relevant to Travere’s areas of interest.

Contribute to identification of new indications or patient populations where an external or internal asset may provide meaningful clinical benefit.

Lead or contribute to scientific interactions with external companies, academic collaborators, CROs, consultants, key opinion leaders, and subject matter experts during diligence and collaboration activities.

Identify and engage external experts to inform evaluation of disease biology, pharmacology, biomarkers, clinical translation, and development risk.

Support assessment of external research proposals, collaboration opportunities, and emerging scientific areas relevant to Travere’s strategic interests.

Represent Travere professionally in conferences, external scientific discussions, diligence meetings, advisory interactions, and collaborative forums.

Interpret pharmacology, toxicology, translational, and biomarker data in the context of potential clinical development and regulatory expectations.

Contribute to evaluation of whether available nonclinical packages are adequate to support current or proposed clinical development plans.

Contribute to development plans and budget for selected opportunities, including translational strategy, nonclinical pharmacology and safety needs, biomarker plans, and early clinical development considerations.

Support preparation and review of relevant sections of investigator brochures, briefing documents, regulatory…