Associate Scientist , Formulation Development

Associate Scientist I

Profoundly Improve People's lives by Revolutionizing the Delivery of RNA Therapeutics

At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people's lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies.

If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients.

Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics
- Antibody Oligonucleotide Conjugates (AOCs™). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is headquartered in San Diego, CA.

We are seeking a highly motivated individual eager to work in a fast-paced and collaborative environment as an Associate Scientist I within the Analytical and Formulation group of Avidity's Technical Development and Operations (TD&O) department. This position will focus primarily on the clinical and commercial formulation development of AOC drug product and drug substance. Additional responsibilities may include but are not limited to supporting the develop ability assessments of early-stage mAb and AOC assets and performing in-use compatibility studies for intravenous and subcutaneous routes of administration.

The successful candidate will have experience in analytical and biophysical characterization, formulation development, and stability testing of protein biologics, preferably for mAbs and antibody-drug conjugates (ADCs). Strong interpersonal, organizational, and communication skills are essential as this position will require close collaboration with cross-functional team members as well as periodic communication with external research organizations and vendors. This position will report to the Principal Scientist within the Analytics and Formulation group, which is laboratory-based at the Avidity site in San Diego, CA.

Non-laboratory functions such as data processing and documentation, however, may be completed remotely.

• Work with TD&O team members to set up and conduct formulation stability studies of mAb and AOC liquid and lyophilized dosage forms
• Perform develop ability assessments of numerous early-stage protein biologics using a variety of predictive analytical and biophysical methods
• Perform routine lab tasks including preparing buffers, managing the inventory of laboratory consumables and supplies, and working with vendors for maintenance and troubleshooting of analytical instruments
• Conduct in-use compatibility studies of AOC drug products intended for intravenous and subcutaneous routes of administration
• Support mAb and AOC drug substance/product process development activities when needed
• Be a hands-on presence in the laboratory and support biology and chemistry departments with analytical and biophysical characterization as needed
• Specify, purchase, and manage the installation of formulation-related instrumentation and equipment
• Maintain good documentation in an electronic notebook and write technical reports as required
• Present data at regular team and cross functional team meetings
• Contributes to the company's core values (agile, visionary, integrated and diverse)

• A bachelor's degree (or master's) in chemistry, biology, pharmaceutical sciences, or a related field with a minimum of 5 years of industrial experience (3 years for a master's degree).
• An understanding of protein physicochemical stability, particularly for common routes of mAb degradation
• Experience…