Formulation Scientist in San Diego

Position Title: Scientist 1

Work Location: San Diego, CA, 92111

Assignment Duration: 12 Months

Work Arrangement: Onsite (laboratory-based role)

Work Schedule: Monday to Friday, 8am-4pm or 9am-5pm

We are seeking a motivated and detail-oriented Scientist 1 to join our Formulation team. In this hands‑on laboratory role, you will work closely with senior scientists to execute and optimize the synthesis of targeted and non‑targeted lipid nanoparticles (LNPs) for nucleic acid delivery.

Support development of the non‑viral delivery platform through LNP formulation for nucleic acid delivery.

• Execute and optimize the synthesis and characterization of lipid nanoparticles (LNPs) encapsulating nucleic acids for in vitro and in vivo studies under the guidance of senior formulation scientists.
• Implement Design of Experiment (DoE) based screening campaigns to evaluate and establish optimal LNP compositions and processing parameters.
• Collaborate cross‑functionally with internal teams to support and fulfill formulation requests.
• Support early‑stage formulation development and downstream processing activities, including cryoprotection, scale‑up, and stability studies.
• Maintain detailed records documenting formulation activities and results.
• Analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management activities, including inventory tracking, supply ordering, buffer preparation, and autoclaving.

• Education: Bachelor’s degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 2+ years of biopharma industry experience, OR a Master’s degree with 1+ years of industry experience.
• LNP Expertise: Minimum of 1–2 years of hands‑on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA).
• Analytical
  
  Skills:
  
  Proficiency with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.
• Skills: Prior experience with Tangential Flow Filtration (TFF), dialysis, and bioconjugation chemistry is highly desirable.
• Software & Data: High proficiency in MS Excel is required; hands‑on experience with statistical and data analysis software (e.g., JMP, Prism) is desirable.
• Core Competencies: Strong attention to detail, a track record of producing reproducible data, excellent organizational skills, and the ability to communicate effectively within a fast‑paced team environment.

For information on benefits, equal opportunity employment, and location‑specific applicant notices, .

At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws.