Protein Manufacturing Specialist

Description

Singular Genomics is inventing at the forefront of genomics, one of the world’s fastest-growing industries. The commercially available G4® Sequencing Platform is a powerful, highly versatile benchtop genomic sequencer designed to produce fast and accurate results. In addition, the company is currently developing the G4X™ Spatial Sequencer, an upgrade to the G4, which will leverage Singular’s proprietary sequencing technology, applying it as an in situ readout for transcriptomics, proteomics and fluorescent H&E in tissue, with spatial context.

Singular Genomics’ mission is to empower researchers and clinicians to advance science and medicine.

We foster a culture of creativity and technical excellence, both catalysts for innovation. We celebrate diversity, emphasize collaboration and, as we rapidly mature, we are constantly looking at ways we can do better for our people.

Our Headquarters are located on the Torrey Pines Mesa, in La Jolla, California at the center of the biotech hub. Our Manufacturing facility is in Sorrento Valley.

As a Protein Manufacturing Specialist II you will be responsible for the production of high-quality enzymes and antibody conjugates to enable Singular’s NGS and Spatial technologies. We are seeking a self-driven individual who enjoys to work independently or collaboratively on a variety of different processes.

• Support the day-to-day setup and operation of laboratory activities and execute laboratory procedures and SOPs as required to meet production needs.
• Apply Good Manufacturing Practices (GMP) within a protein production environment, including maintaining standards for sterility, bacterial growth, and fermentation processes.
• Independently perform protein expression using bioreactors and protein purification using ÄKTA systems in accordance with established manufacturing protocols.
• Execute cell lysis, cell harvesting, centrifugation, chromatography, and other protein purification techniques.
• Support antibody conjugation activities.
• Maintain accurate and comprehensive documentation in a production environment, including batch records, process data, and presentation materials.
• Perform routine quality control testing, including SDS-PAGE, protein concentration determination, and basic protein characterization assays.
• Deliver high-quality work with strong attention to detail while effectively managing multiple priorities.
• Troubleshoot technical issues, identify root causes, and recommend solutions.
• Work independently with moderate supervision while ensuring compliance with established procedures and timelines.
• Collaborate effectively with cross-functional teams, including R&D, Reagents Manufacturing, and Quality Control.
• Adhere to all Environmental Health & Safety (EH&S) policies, procedures, and regulatory requirements.

• Hands-on experience in protein expression and purification.
• Proficiency with ÄKTA chromatography systems and associated purification workflows.
• Strong laboratory skills, attention to detail, and ability to maintain accurate documentation in a regulated environment.
• Ability to troubleshoot technical challenges and work effectively in a fast-paced, team-oriented setting.
• Bachelor’s degree in Life Sciences or a related field with a minimum of 3 years of relevant industry experience, or an equivalent combination of education and experience.

• Experience operating bioreactors for microbial protein expression.
• Experience with antibody conjugation processes.
• Familiarity with GMP manufacturing environments and quality systems.

The estimated base salary range for this role based in the United States of America is: $23.98 - $29.62. Additionally, this role is eligible for to receive equity as part of the compensation package. Compensation decisions are dependent on several factors including, but not limited to, an individual’s qualifications, location where the role is to be performed, internal equity, and alignment with market data.

Should the level of the role change during the hiring process, the applicable salary range may be updated accordingly.

Singular Genomics is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

Singular Genomics is committed to working with and providing reasonable accommodations to job applicants with physical or mental disabilities. Applicants with a disability who require a reasonable accommodation for any part of the application or hiring process can provide their name and contact information to our Accommodations team at accommodation Your request will be responded to as soon as possible.