Associate Scientist, In Vivo Pharmacology

Working with Us

Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

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The Pharmacology group within the Protein Homeostasis Thematic Research Center (TRC) at BMS San Diego provides in vivo pharmacology support to discovery teams focused on developing small molecules and biologics for oncology and immune-oncology. As an integral part of discovery programs, the group supports lead identification through in vivo model screening and mechanism-of-action studies, develops and validates animal disease models, identifies pathway biomarkers, and establishes clinically relevant endpoints to assess efficacy.

Collaboration with DMPK, Exploratory Toxicology, and Translational Development is central to our work, and we contribute preclinical data to inform clinical development plans.

We are seeking a motivated Associate Scientist with broad experience in pharmacology and drug discovery for both small and large molecules. The successful candidate will work collaboratively in a multidisciplinary environment, taking responsibility for experiment design, planning, and execution. Key duties include interpreting and presenting in vivo data, conducting sample and endpoint analyses (ELISA, Western blot, Jess, qPCR, IHC), and preparing protocols and reports.

The role requires independent work, technical expertise, and contributions to project decisions. Strong communication, self-motivation, innovation, flexibility, and teamwork are essential.

In the role as an Associate Scientist within Pharmacology, the ideal candidate will be responsible for the following:

• Develop disease models for oncology and immune-oncology
• Independently design and execute in vivo efficacy and PK/PD experiments to identify drug candidates
• Analyze and interpret data accurately, reporting findings to supervisors and colleagues
• Troubleshoot routine issues and recommend solutions
• Evaluate endpoints from in vivo studies using Western blots, mesoscale, qPCR, etc.
• Write precise protocols and technical reports
• Present data to multidisciplinary discovery teams
• Collaborate with cross-functional team members

• Bachelor’s Degree
• 2+ years of academic and / or industry experience with oncology models

• Experience in mammalian cell culture
• Experience in the development of syngeneic and xenograft cancer models
• Proficient in animal handling, dosing (PO, IP, IV, and SC), tumor cell inoculation, data collection and analysis
• Hands-on experience in small animal surgeries, necropsy and tissue and blood collection
• Hands-on experience in evaluating small molecules in animal models
• Experience with small animal imaging modalities (e.g., Xenogen, ultrasound etc.) is a plus.
• Skilled in Western blots, ELISA, Meso Scale, IHC, flow cytometry, RNA/DNA extraction, and PCR
• Proficient in Excel, Word, PowerPoint, Flow Jo, Graph Pad Prism, and Studylog
• Excellent interpersonal, communication, presentation, collaboration, and organizational skills
• Detail-oriented, focused, and able to deliver high-quality data efficiently

#LI-Onsite

San Diego - CA - US: $93,230 - $112,970

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account…