Scientist I ​/ Scientist II, Cell-based High Throughput Screening

We are seeking a Scientist to join our Lead Discovery team with a focus on cell-based high-throughput screening (HTS). This position may be filled at the Scientist I or Scientist II level based on the selected candidate’s education, experience, technical depth, demonstrated accomplishments, and ability to operate independently. The successful candidate will contribute directly to small-molecule drug discovery programs by developing, executing, and analyzing robust, miniaturized cell-based assays in a fast-paced biotechnology environment.

• Design, develop, optimize, and execute robust, reproducible cell-based assays to support high-throughput screening, hit confirmation, and hit-to-lead campaigns.
• Culture, maintain, characterize, and bank mammalian cell lines used in screening and assay-development workflows.
• Apply assay miniaturization, automation, and statistical quality-control principles to generate reliable screening data in 96-, 384-, and 1536-well formats.
• Collaborate closely with biology, chemistry, automation, compound management, and data teams to plan and execute screening campaigns.
• Troubleshoot assay performance, cellular readouts, liquid-handling methods, and sources of screening variability.
• Analyze, interpret, and clearly communicate experimental and screening results in internal meetings, written reports, and electronic systems.
• Maintain complete and timely documentation in electronic laboratory notebooks and other applicable data-management systems.
• Contribute to the development, standardization, and continuous improvement of screening workflows, assay-quality practices, and automation processes.
• Support assay transfer, validation, and implementation on automated HTS platforms.
• Perform other duties as assigned.

• Develop technical proficiency in cell-based assay development, mammalian cell culture, and HTS operations while contributing independent thought and scientific creativity.
• Work on problems of moderate scope, using established procedures and identifiable data factors to determine appropriate actions.
• Perform routine work with general instruction and complete new or unfamiliar assignments with more detailed guidance.
• Independently develop and optimize assays and solve a wide range of difficult technical problems using imaginative and practical approaches.
• Work across projects of diverse scopes, evaluate relevant data factors, and select methods and techniques within generally defined practices.
• Operate independently on routine work and receive general directions on new assignments.
  • Multi-mode plate readers such as EnVision, PHERAstar, and Clario Star for luminescence, fluorescence, absorbance, and time-resolved fluorescence.
  • Flow cytometry platforms, including Cytek Biosciences systems, for cell-based screening applications.
  • Echo acoustic dispensers for low-volume, non-contact liquid dispensing.
  • LGR Precise Drop or comparable low-volume reagent and cell-dispensing systems.
  • Tecan Freedom EVO/Fluent, Hamilton Microlab STAR/NIMBUS, or Beckman Biomek platforms for pipetting, dilution, plate manipulation, and method optimization.
  • Compound storage and retrieval systems, automated incubators, robotic plate handling, barcode tracking, and LIMS integration.
  • Automated screening workflows connecting assay requests, compound plates, liquid handling, detection, and data systems.
  • Cell-based and biochemical assay development, miniaturization, validation, statistical analysis, and quality-control assessment.
  • Primary and secondary screening campaign execution, hit identification, data review, and comprehensive screening documentation.

Programs and systems may include:

• Detection Instrumentation
• Automated Liquid Handling Systems
• Laboratory Automation Infrastructure
• Assay Development and Screening Operations

• Degree in Biology, Pharmacology, Biochemistry, Cell Biology, or a related scientific discipline, or an equivalent combination of education and relevant industry experience.
• Level will be determined based on the candidate’s qualifications and alignment with the following general experience guidelines:
  Scientist I— PhD with relevant…