Assoc. Scientific Director, Pharmacometrics

About the Role

The Associate Director, Pharmacometrics leads the pharmacokinetic (PK) and pharmacodynamic (PD) modeling and simulation (M&S) efforts that drive the clinical development of Neurocrine’s small- and large-molecule programs. The role provides strategic expertise in PK/PD methodology, performs or oversees pharmacometric analyses, and clearly communicates findings to cross‑functional stakeholders. It also contributes to the design and execution of the Clinical Pharmacology and Pharmacometrics Development Plan.

By applying innovative quantitative approaches to guide key development decisions, the Associate Director enhances program efficiency, scientific quality, and regulatory readiness. The role further demonstrates leadership by mentoring colleagues and directing critical projects, advancing excellence within the Pharmacometrics function.

• Lead pharmacometrics tasks and serve as function lead for assigned clinical development program.
• Recommend strategic direction for modeling and simulation activities for various projects.
• Independently conduct and report population PK, PK/PD, and Exposure-Response analyses to support dose selection, clinical trial design and regulatory submissions.
• Oversee the design and reporting of M&S analyses conducted by external Contract Research Organizations (CROs).
• Contribute to the M&S sections for internal decision‑making boards, regulatory documents, interactions and responses.
• Prepare posters, publications, presentations for internal and external conferences in quantitative pharmacology and pharmacometrics science.
• Serve as a mentor and may direct projects of critical importance.
• Perform other duties as assigned.

• PhD, PharmD, or equivalent in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Chemistry, Biochemistry, or related field with a specific focus on PK and PK/PD modeling and simulation.
• 5+ years of drug development experience post PhD/PharmD OR MS and 8+ years of Pharmaceutical/Biotech industry experience.
• Expert knowledge in conduct and/or oversight of early and late-stage Modeling and Simulation activities.
• In‑depth knowledge of all stages of clinical drug development, including preparation of components of the Clinical Pharmacology sections of Regulatory submissions for IND- and NDA-stage projects.
• Proficient with the use of PK and PK/PD modeling software tools including NONMEM, R and Win Nonlin.
• Significant expertise in preparing NDA/MAA summaries of population modeling analyses.
• Strong communications, problem-solving, analytical thinking, and influencing skills.
• Ability to work in a cross‑functional team and matrix environment.
• Good leadership and mentoring skills, typically leading lower levels and/or indirect teams.
• Ability to meet multiple deadlines across a variety of projects/programs with a high degree of accuracy and efficiency.
• Excellent project management and leadership skills.

Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.

The annual base salary range is $–$, with individual pay decisions influenced by location, role complexity, responsibilities, and relevant experience and skills. The position offers an annual bonus target of 30% of the earned base salary and eligibility for participation in an equity‑based long‑term incentive program. Benefits include a retirement savings plan with company match, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits covering medical, prescription drug, dental and vision in accordance with plan terms.