Research Scientist, Peptide Chemistry

Research Scientist

Cali
-Skaggs Institute for Innovative Medicines, a division of Scripps Research, is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Scripps Research is ranked one of the most influential institutions in the world for its impact on innovation. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Leveraging the unique scientific environment of Scripps Research, impacting translational sciences, Cali
-Skaggs has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Cali
-Skaggs' drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected diseases, as well as age-related and degenerative diseases. If you have a passion for making a difference, this could be your opportunity to join our transformative team.

POSITION SUMMARY:

We are seeking an experienced and highly skilled Peptide Chemist to join our dynamic team in San Diego. The ideal candidate will possess exceptional academic credentials in peptide medicinal chemistry, along with expertise in formulation strategies for peptide therapeutics.

In this role, the successful applicant will be a key member of the laboratory, contributing to the design and synthesis of peptide analogs intended to enhance the potency, pharmacokinetics, stability, and in vivo efficacy of potential drug candidates, with a particular focus on long-acting injectable formats.

The candidate will have ample opportunity to participate in multidisciplinary drug discovery projects, engage in independent ideation, and help drive innovative practices that accelerate peptide drug discovery efforts. This role offers strong potential for career growth in a collaborative, cutting-edge environment.

RESPONSIBILITIES:

• Play a leadership role in peptide drug discovery and development efforts, contributing to the advancement of long-acting peptides and peptide conjugates into effective clinical candidates.
• Participates in a multidisciplinary team committed to the expeditious identification of development compounds and advancing discovery projects through critical preclinical stage gates.
• Apply medicinal chemistry and formulation principles to optimize peptide candidates for extended-duration dosing.

REQUIREMENTS:

• Master's degree with a minimum of 5 years of relevant industry experience, or Bachelor's degree with 10+ years of experience.
• Ph.D and/or postdoc in chemical or biological sciences with a strong focus on peptide chemistry is preferred.
• 1-4 years of experience in academia or a biotechnology/pharmaceutical company.
• Skilled in contemporary peptide synthesis techniques, and analytical characterization of peptides and proteins.

ADDITIONAL PREFERENCES:

• Strong understanding of peptide and protein structure and associated biophysical techniques to assess structure, stability and behavior in solution.
• Experience in bioconjugation, time-extension and formulation strategies for peptides and proteins.
• Review research papers and intellectual property literature in support of SAR of peptide drug design and/or delivery.
• Demonstrated ability to work independently as well as in cross-functional team
• Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency
• Self-motivated, strong work ethic, independent and results oriented.

PHYSICAL REQUIREMENTS:

This position works in a laboratory environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

COMPENSATION:

The expected hiring range for this position is $77,000 - $95,000 per year, commensurate with experience. Consideration will be given to experience that…