Senior Scientist, Process Development-Cell Based Assay

Company Description

BPS Bioscience Inc. is a leading developer and manufacturer of research tools for various scientific fields, including bromodomains, CAR-T therapy, cell signaling pathways, Coronavirus, CRISPR, deacetylases, demethylases, immunotherapy, kinases, methyltransferases, phosphodiesterases, phosphatases, poly ADP ribose polymerases, and ubiquitin enzymes. The company is headquartered in San Diego, California and provides custom protein expression, biochemical and cell-based assays, cell line development, CRISPR, BLI and compound screening services.

BPS Bioscience is scientist founded and driven, focusing on providing quality life science products and services to accelerate drug discovery and development for treatment of human diseases.

BPS Bioscience Inc. is a leading provider of recombinant proteins, assay kits, recombinant cell lines, and viral tools for drug discovery. We are seeking an exceptional senior scientist with a strong background in cell biology, mammalian cell culture, signal transduction, reporter gene systems, and functional cell-based assay technologies, including luciferase reporter assays, GPCR assays, immune checkpoint pathway assays, and immune effector cell functional assays.

The ideal candidate will bring excellent experience in the validation of engineered cell lines, including gene over-expression, knock-in, and knockout models, as well as hands‑on expertise in the validation and characterization of lentiviral and AAV-based products. Strong flow cytometry proficiency is required, including multicolor panel design, data analysis, and cell sorting for both research and manufacturing QC applications.

The Senior Scientist, Process Development - Cell Based Assay, will lead the design, optimization, and scale‑up of robust manufacturing and QC processes for BPS Bioscience’s cell-based product lines, including stable reporter cell lines, transient transfection systems, cell-based assay kits, and related biological reagents. This is a hands‑on, lab bench role; the ideal candidate will actively perform laboratory experiments, validate and transfer new cell-based products and processes from R&D to manufacturing and quality control, and establish product specifications.

The position requires direct expertise in cell line engineering, process characterization, technology transfer, and continuous improvement, supporting the delivery of high‑quality products. The candidate must be highly skilled in cell-based assay development, mammalian cell culture, transfection, cell line engineering, and functional assay qualification. The ideal candidate will work with minimal guidance, execute experiments to a very high standard, troubleshoot technical and scientific problems, and effectively progress multiple projects simultaneously.

• Lead the design, validation, and optimization of manufacturing and QC processes for BPS Bioscience’s cell-based products, including stable luciferase reporter cell lines (HEK
  293, Jurkat, Raw
  264.7, CHO, and others), transient transfection assay kits, immune checkpoint reporter cell lines, CAR‑T/NK cell functional assay tools, and GPCR/ion channel assay systems.
• Characterize and validate stable cell lines using lentiviral transduction, plasmid transfection, CRISPR/Cas9 gene editing, and selection‑based cloning strategies; confirm identity, stability, and functional performance through molecular and phenotypic characterization.
• Qualify and validate cell-based assay methods including luciferase reporter assays, HTRF, FRET, BRET, cAMP, calcium flux, cytokine release, cytotoxicity (ADCC, CDC), proliferation, and flow cytometry-based assays in compliance with GLP and ISO 9001:2015 standards.
• Validate and transfer new cell-based products and processes from R&D to manufacturing and quality control, ensuring seamless technology transfer, process robustness, and implementation across production scales.
• Establish product specifications, release criteria, and QC methods for cell-based products; set and refine acceptance criteria for critical quality attributes including cell viability, passage number limits, mycoplasma testing, stability…