Senior Scientist, Discovery Biology San Diego - CA - US R1605506 Posted a day ago

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The Protein Homeostasis Thematic Research Center at BMS is a fundamental Oncology research engine delivering oncology and hematology therapeutics to patients. The TRC has a major focus on exploiting BMS’ expertise in protein degradation to discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance to existing cancer therapeutics. This focus on protein degradation allows us to attack protein classes that were previously deemed undruggable.

We are seeking a highly motivated Cancer Biologist to join the Molecular Pharmacology discovery biology team at the Protein Homeostasis TRC in San Diego, CA. The qualified candidate should be a self‑motivated and creative cancer biologist who possesses substantial expertise in and passion for cancer biology and genetics, with a keen eye for novel therapeutic opportunities to address well defined patient populations.

The individual will support and lead the discovery of novel targeted protein degradation drugs for solid tumour. The successful candidate will be expected to work collaboratively in a multi‑disciplinary environment to explore disease biology enabling identification of novel drug targets; develop and implement robust cellular assays to support discovery of small molecules as clinical development candidates; design and execute research strategies that further our understanding of the mechanisms of novel compounds and targets;

and develop collaborations and interact with external partners relevant to the target discovery efforts. The desired candidate should have broad experience in cancer biology and in vitro cell culture techniques and a willingness to learn and adapt to any direction a project may take them. The candidate is expected to be able to work as an independent scientist, but also extensively collaborate or coordinate with other functional areas and contribute as part of a team to make project-based decisions.

The successful candidate will demonstrate strong verbal and written communication skills, capable of presenting scientific results to multidisciplinary teams. This role is a primarily bench‑facing cancer biology research position.

• Based on literature and internal data, formulate mechanistic hypothesis for drug discovery projects and design and execute experiments to test these hypotheses
• Find, establish, and execute techniques or assays that are key for understanding mechanism of action of selected compounds/targets
• Develop new drug discovery projects based on literature and mining of existing data sets
• Utilize and develop disease models to design target validation studies and relevant assays in support of SAR
• Collaborate with colleagues in other functional areas including informatics and translational research to generate testable hypotheses that will validate novel targets and solidify patient selection hypotheses
• Accurately maintain written reports and present results in an organized and timely manner
• Communicate effectively, foster teamwork and contribute to project strategy discussions
• Strong commitment to quality and demonstrate adaptability

• Bachelor’s Degree
• 7+ years of academic and / or industry experience

• Ph.D. degree in cancer…