Scientist, Protein Production and Characterization

Scientist Position

We are seeking a highly motivated and skilled Scientist to join our Protein Sciences team and contribute to both day-to-day operations and the advancement of Protein Science workflows. This position will focus on the design, optimization, and execution of transient transfection processes at various scales for antibody and protein production in mammalian expression systems. The successful candidate will leverage expertise in biophysical characterization and biochemical modification to evaluate key protein attributes.

This position will report to the Associate Director of Protein Sciences and work closely with scientists in the Antibody Discovery, Antibody Engineering, Protein Sciences, and Project Management teams. The ideal candidate will drive innovation through process refinement and high-throughput automation, while advancing develop ability and purification strategies for novel biologic formats. This role offers the opportunity to work in a fast-paced, collaborative research environment, where creative solutions and a strong scientific approach are key to success.

Independently design and execute transient transfection workflows for antibodies and proteins in various mammalian expression systems

Provide leadership in protein purification by designing and improving methods for throughput, quality, and efficiency

Drive develop ability assessment efforts by designing and executing analytical studies to evaluate protein stability, purity, and key biophysical characteristics

Support production of complex construct design strategies (e.g., VLPs, nanodiscs), to enable immunization of challenging targets

Execute high throughput processes to support protein production workflows using Bravo and other robotic platforms

Effectively maintain meticulous records of lab activities using electronic notebook (Benchling); communicate findings clearly through written reports and presentations to support project progression and scientific decision-making

Contribute innovative ideas and collaborate effectively across teams to drive research excellence and project success in a fast-paced environment

Ph.D. in Biochemistry, Chemistry, Molecular Biology, Protein Engineering, or a related field with 1-3 years of industry experience or MS with 5-7 years of direct industry experience is required

Proven hands-on experience with multiple mammalian expression platforms is required

Proficiency with AKTA instrumentation, demonstrating a broad range of standard and specialized purification (e.g., affinity, ion exchange, HIC and SEC) and protein QC techniques is required

Experience with therapeutic antibody develop ability assessment is highly desirable

Strong analytical, troubleshooting, and communication skills with meticulous attention to detail

Motivated self-starter with excellent organization, teamwork, and a passion for scientific innovation

About Aliva Mab Biologics

Aliva Mab Biologics sets its partners' antibody discovery programs on the fastest and most de-risked path through discovery and development. Trusted by top-tier pharmaceutical and biotechnology companies, AMB delivers drug-quality, fully human antibodies on exceptional timelines. AMB achieves its partners' design goals, from simple to extraordinarily challenging, through the generation and function-first screening of large, molecularly diverse panels of antibodies. AMB focuses on rapid and efficient delivery of antibodies, characterized for function, kinetics and develop ability, and engineering for alternative formats, including multi-specifics and CARs.

The AMB team's experience and passion for antibody drug discovery and development combined with the use of trusted, proven technologies, including Ablexis' Aliva Mab® Mouse platforms, ensure the highest probability of success.

Aliva Mab Biologics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion or creed, sex, sexual orientation, gender, gender identity or expression, pregnancy, childbirth or related medical conditions, reproductive health decision-making, national origin, ancestry, age, physical or mental disability, medical condition, marital status, citizenship or immigration status, veteran or military status, or any other characteristic protected by applicable federal, state, or local law.

Salary Range: $118,000 - $145,000 annually