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Senior Scientific Director, Protein Engineering
Job in
San Diego, San Diego County, California, 92189, USA
Listed on 2026-09-12
Listing for:
Scorpion Therapeutics
Full Time
position Listed on 2026-09-12
Job specializations:
-
Research/Development
Biotech Research, Research Scientist, Drug Discovery
Job Description & How to Apply Below
About The Role
Senior Scientific Director, Protein Engineering provides scientific and strategic leadership for Neurocrine’s protein engineering and biologics discovery capabilities. Leads a team of protein engineers and expands technical expertise/platforms to enable next-generation biotherapeutics.
Your Contributions Scientific Leadership- Lead and provide strategic direction for the Protein Engineering function; set scientific priorities for the biologics portfolio
- Guide programs from target assessment through lead generation, optimization, candidate selection, and transition into development
- Drive innovation in antibody and protein engineering technologies
- Evaluate and implement emerging technologies, platforms, and computational approaches
- Lead, mentor, and develop protein engineering talent; recruit additional scientific talent
- Foster a collaborative, innovative, inclusive scientific culture
- Build capabilities via investment in new technologies, workflows, and expertise
- Establish/maintain collaborations with CROs, academics, and technology providers
- Partner cross-functionally to advance biologics programs through discovery and IND-enabling studies
- Lead candidate selection, develop ability assessment, and optimization strategies
- Provide data-driven recommendations for governance and portfolio decisions
- Ensure protein engineering work aligns with timelines, quality standards, and objectives
- PhD (10+ years) OR Master’s (20+ years) OR Bachelor’s (22+ years) in relevant discipline
- Demonstrated scientific leadership advancing antibody/protein therapeutics from discovery through IND-enabling development
- Extensive expertise in protein/antibody engineering and structure-function relationships
- Expertise in protein conjugation, multispecifics, ADCs, or other next-gen biologics
- Experience leading high-performing scientific teams and building protein engineering capabilities
- Deep knowledge of biologics discovery workflows (molecular design, lead optimization, develop ability, candidate selection)
- Strong construct design, recombinant expression (mammalian/microbial), purification, biochemical/biophysical characterization
- Knowledge of antibody discovery technologies (e.g., display platforms, affinity maturation, engineered scaffolds)
- Experience managing CRO/external collaborations; strong publication/patent record
- Excellent scientific communication; ability to translate strategy into executable plans
- Experience developing therapeutic antibodies/biologics in neuroscience, endocrinology, immunology, or inflammation
- Computational protein design, ML-enabled engineering, or AI-assisted design
- High-throughput screening, protein display, develop ability assessment
- Familiarity with LC-MS characterization
- Knowledge of regulatory expectations for IND submission
Position Requirements
10+ Years
work experience
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