Senior Scientist , Computational Biology; targetID

At HAYA Therapeutics, we are pioneering a new class of programmable RNA-guided therapeutics that target the regulatory genome to reprogram disease-driving cell states. By decoding the causal biology of pathological cell states and the long-noncoding RNAs (lncRNAs) that regulate them, HAYA translates these insights into tractable therapeutic candidates designed to address disease at its source and restore cellular health. HAYA is advancing a broad pipeline of RNA-guided medicines for chronic, age-related diseases.

Recognized globally for our scientific innovation, HAYA has been named a 2025 Technology Pioneer by the World Economic Forum (WEF), selected for Bio Space's Next Gen Bio Class of 2026, recognized as a 2026 Disruptive Pioneer by IDEA Pharma, and celebrated as one of the Top Innovative Companies in Switzerland for 2025. As a fast-growing biotech, we offer an entrepreneurial, science-driven environment where you’ll have a direct impact on shaping our pipeline and advancing RNA medicine

1. Purpose of the role:

Execute Target Discovery and Validation activities  withinthe Data Science teamtoidentifyandvalidatecell-state driving disease-modifyinglncRNAsand regulatory elements by integrating multi-omicstranscriptomics and epigenomicsdatasets, withmain focusonimmunology and inflammatory indications

2. Accountabilities

• Preprocess and analyze raw multi-omics datasets (including bulk/single-cell/single-nuclei RNA-seq, ATAC-seq, PRO-seq, CUT&RUN, 3D genomics) to characterize the regulatory genome driving cell states and extract the features to perform target identification.
• Integrate human genomic, genetic, and epigenetic datasets (including GWAS,eQTLs, and chromatin conformation annotations) with internal transcriptomic pipelinestoidentifypotent cell-state drivinglncRNA targets.
• Translate high-dimensional omicsanalysis and results into clear, biologically grounded scientific presentations and documentationtofacilitatestrategicalignment, influence multi-disciplinary program stakeholders, and support executive decisions.

Requirements

3. Required Knowledge and Experience

Essential Qualifications & Technical Capabilities (Must-Haves)

• PhD in Computational Biology, Bioinformatics, Computer Science, Genomics, or a related quantitative or life sciences field with a robust computational focus; or equivalent demonstrated capability and technical depth.

• Proficient programming skills in R or Python, supported by strong data hygiene, and a desire to build sharedreproducibletoolkitsand pipelines.

• Experience onthe identification ofnoveltargets,demonstratinga strong drive to design andleveragecomputational workflows with minimal supervision.

• Deep technicalproficiencyin preprocessing, integrating, and analyzing multi-omics datasets, specifically bulk and single-cell/single-nuclei RNA-seq, ATAC-seq, PRO-seq, and CUT&RUN, to definecellstates andidentifybiological drivers within the regulatory genome.

• Excellent scientific understanding of gene regulation, transcriptomics, and the non-coding genome (in particularlncRNAs) andgene regulatory networks.

• Proven capability in presenting complex multi-omicsstatistical analyses, and data science concepts in a clear, narrative-driven manner to both technical, biological, and non-expert stakeholders, serving as a bridge between dry and wet lab activities.

HAYA Therapeutics is an Equal Opportunity Employer committed to fostering a diverse, inclusive, and equitable workplace where all individuals feel valued and empowered. We provide equal employment opportunities to all qualified applicants and employees without regard to race, color, religion, sex (including pregnancy, sexual orientation, gender identity, or gender expression), national origin, ancestry, age, marital or familial status, veteran status, disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws.

We prohibit discrimination and harassment of any kind and are committed to ensuring fair and equitable treatment in all aspects of recruitment, hiring, promotion, compensation, benefits, training, and career development. At HAYA, we believe that diversity of thought, experience, and background drives innovation and strengthens our mission to transform patient care through cutting-edge RNA-based therapeutics.

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