Research Technician II - Jin Lab

Primary Work Address: 10550 North Torrey Pines Road, La Jolla, CA,92037

The Howard Hughes Medical Institute (HHMI) advances the discovery and sharing of scientific knowledge to benefit us all. As a biomedical research organization and philanthropy, HHMI supports a vibrant community of academic researchers, educators, students, and professionals. Together, we’re unlocking the fundamentals of biology and building an open, inclusive future for science.

to join Dr. Xin Jin’s lab at Scripps Research in LaJolla, California. The Jin lab is investigating how physiology and genetics impact brain function to understand how these distinct influences converge in the developing brain. To tackle these questions, they combine in vivo CRISPR screening with single-cellmulti-omics, spatial genomics, and chemical biology tools. Theirwork is deeply collaborative, both within the lab and acrossdisciplines, and bridges cutting-edge neurotechnology withfundamental questions in brain development.

This integration oftool-building and mechanistic insight positions them to uncover howdiverse inputs shape the brain’s trajectory in health and disease. More information about the lab and their work can be found by visiting https://(Use the "Apply for this Job" box below)./

As the Research Technician II, you will support studies usinggenomic tools to investigate tissue development and homeostasis. This position will involve mouse handling, molecular biology, genomics, cell culture, and single-cell sequencing-relatedworkflows. The successful candidate will work both independently and collaboratively to perform experiments, maintain accurate records, troubleshoot protocols, and help generate high-quality data for ongoing research projects. This is an ideal opportunity for someone who is passionate about the lab’s work and looking fora stable, longer-term (ideally 3+ years) career experience.

• An energetic, dynamic, and fun lab team that values innovation,inclusion, scientific rigor, and collaboration.
• Generous and stable research funding from HHMI.
• Joining the vibrant Scripps research community.
• Career growth, skill building, and professional development.
• Opportunities to be mentored by Dr. Jin and/or senior membersof the team.
• Opportunities for authorship/co-authorship on research publications.
• A competitive compensation package with comprehensive health and wellness benefits.

• Perform mouse-related laboratory work, including handling,husbandry coordination, colony tracking, genotyping, tissuedissection/collection, and molecular analysis, in support ofstudies on brain development and neurodevelopmental diseasemechanisms.
• Assist with CRISPR-based perturbation experiments, includingreagent preparation, viral/vector-related workflows, sample collection, and genomic analysis.
• Carry out core molecular biology techniques, including DNA/RNAextraction, PCR, qPCR, gel electrophoresis, cloning, and preparation of sequencing-related materials.
• Support single-cell genomics workflows, including nuclei/cellpreparation, quality control, library preparation support, andsample submission for sequencing.
• Maintain mammalian cell cultures using sterile technique,including passaging, transfection/transduction support, and monitoring of cell health.
• Prepare, organize, and validate experimental reagents, such asplasmids, oligos, guide RNA libraries, buffers, and cell culturemedia.
• Record experimental procedures, sample information, and results accurately in laboratory notebooks and shared databases.
• Analyze and summarize experimental results, includinggenotyping outcomes, QC metrics, and molecular assay data, and troubleshoot routine issues related to sample quality, molecularassays, sequencing preparation, or cell culture conditions.
• Maintain laboratory equipment, supplies, and reagentinventories, and coordinate with lab members on experimentaltimelines, animal use, sequencing submissions, and sample trackingto ensure efficient day-to-day lab operations.
• Adhere to institutional biosafety, animal research, and laboratory compliance policies, including required documentation and training.

• A bachelor’s…