Scientist I​/Scientist II, T Cell Immunology

Scientist I/Scientist II, T Cell Immunology

Avalon Bio Ventures is a biotech venture capital firm that builds on Avalon’s 40-year success in pursuing disruptive ideas to improve life. From its established offices and labs on the Torrey Pines Mesa, in La Jolla, California, Avalon Bio Ventures leverages its Accelerator, which provides operational infrastructure and support, and the team’s extensive experience to identify promising science, build agile companies, and advance breakthrough therapeutics.

Avalon Bio Ventures is a biotech venture capital firm that builds on Avalon’s 40-year success in pursuing disruptive ideas to improve life. From its established offices and labs on the Torrey Pines Mesa, in La Jolla, California, Avalon Bio Ventures leverages its Accelerator, which provides operational infrastructure and support, and the team’s extensive experience to identify promising science, build agile companies, and advance breakthrough therapeutics.

We are seeking a highly motivated and skilled Human T Cell Immunologist to join our team in the development of cutting-edge Regulatory T cell therapies. This role is 100% lab based and will involve researching and advancing innovative therapeutic approaches utilizing regulatory T cells to treat inflammatory diseases, with initial focus in respiratory indications. The ideal candidate will have a strong background in immunology, cellular biology, therapeutics discovery, recombinant DNA methodologies including familiarity with viral expression vectors, and a working knowledge of human T cell biology.

• Design and conduct cutting-edge research to understand the biology of regulatory T cells (Tregs), their function, and therapeutic potential.
• Develop and optimize protocols for isolating, expanding, and modifying Tregs ex vivo for therapeutic applications using viral and non-viral modification.
• Investigate the mechanisms by which Tregs interact with other immune cells and tissues to modulate immune responses.
• Study the effects of engineered Tregs in preclinical in vitro and in vivo models and assess their safety, efficacy, and biological activity.
• Analyze immune cell profiles, cytokine production, and T cell tissue homing and function, to optimize T cell-based therapies.
• Conduct immune cell characterization using flow cytometry, ELISA, PCR, RNAseq, and other relevant techniques.
• Contribute to the generation of data for regulatory filings, research publications, and presentations to senior management.
• Stay updated on the latest developments in regulatory T cell biology, cellular therapies, and immunotherapy research to inform product development strategies.
• Analyze experimental data using bioinformatics tools and statistical methods to assess the effectiveness of Treg therapies.
• Maintain detailed records of experiments, including data analysis and results, in accordance with Good Laboratory Practice (GLP).
• Communicate research findings to internal stakeholders, including senior management, and external collaborators.

• Ph.D. in Immunology, Cell Biology, Cellular Engineering, Molecular Biology, or a related field or MS plus 6-8+ years’ industry experience; experience in T cell biology or T cell immunotherapy is highly desirable plus 1-5+ years lab experience
• Strong foundation in human T cell immunology, with a demonstrated understanding of T cell biology, subsets, and function; working knowledge of regulatory T cell biology with a focus on therapeutic development is highly desirable.
• Hands-on experience with primary human immune cell isolation, activation, culture, and expansion, performed under aseptic conditions
• Demonstrated experience building and running >10-color flow cytometry…