Principal Scientist
Job in
San Diego, San Diego County, California, 92189, USA
Listed on 2026-09-14
Listing for:
Scorpion Therapeutics
Full Time
position Listed on 2026-09-14
Job specializations:
-
Research/Development
Research Scientist, Biotech Research, Drug Discovery, Immunology Research
Job Description & How to Apply Below
Role:
Principal Scientist leading antibody engineering initiatives within Bristol Myers Squibb's Therapeutic Discovery Sciences Department, focusing on early-stage research and platform technology development for recombinant antibody therapeutics.
Responsibilities:- design, execute, and troubleshoot workflows for affinity maturation, humanization, format conversion, and characterization of diverse antibody formats (IgG, Fab, scFv, bispecifics)
- analyze biophysical properties using SEC, SPR/BLI
- collaborate across discovery, structural biology, computational biology, and other teams
- evaluate emerging technologies including AI/ML
- author technical documentation and lead scientific discussions.
- PhD in protein science, structural biology, biochemistry, or related field
- 4+ years of relevant industry or academic experience
- hands-on expertise in antibody design, expression, purification, and characterization
- experience with protein interaction assays like SPR/BLI
- proven independent experiment planning and troubleshooting skills
- scientific leadership with impactful publications or patents.
- experience with advanced antibody formats, bioinformatics, structural techniques, and therapeutic areas such as oncology or immunology
- prior biotech or pharma experience.
- biologics
- antibody engineering
- early discovery
- biophysical characterization
- platform development
- cross-disciplinary collaboration.
laboratory-based role in San Diego, CA.
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