Scientist, Antibody Production and Characterization

Overview

We are seeking a highly motivated and skilled Scientist to join our Protein Sciences team and contribute to both day-to-day operations and the advancement of Protein Science workflows. This position will focus on the design, optimization, and execution of transient transfection processes at various scales for antibody and protein production in mammalian expression systems. The successful candidate will leverage expertise in biophysical characterization and biochemical modification to evaluate key protein attributes.

This position will report to the Associate Director of Protein Sciences and work closely with scientists in the Antibody Discovery, Antibody Engineering, Protein Sciences, and Project Management teams. The ideal candidate will drive innovation through process refinement, high-throughput automation, and growing proficiency of chemical conjugation techniques. This role offers the opportunity to work in a fast-paced, collaborative research environment, where creative solutions and a strong scientific approach are key to success.

Aliva Mab Biologics is a rapidly growing leader in the discovery of human antibody therapeutics, trusted by top-tier pharmaceutical and biotechnology companies to deliver panels of drug-quality human antibodies. We deliver on our partners' design goals, from simple to extraordinarily challenging, through collaborative access to our scientists' creativity and experience combined with proven technologies, including the Aliva Mab® Mouse suite of transgenic mice.

We excel in the rapid and efficient delivery of molecularly diverse therapeutic antibody candidates, well-characterized for function, kinetics, and develop ability, with expanding capabilities for engineering advanced modalities, including multispecifics, single-domain human VH antibodies. Our organization is dedicated to creating a healthier world through partnerships that bring better medicines to patients faster, and we recognize our success starts with hiring people who share our passion for science.

• Independently design, execute and optimize transient transfection workflows for antibodies and proteins in various mammalian expression systems
• Troubleshoot and refine current Protein Science processes, for throughput, quality, and efficiency, as needed
• Design and conduct small to mid-scale antibody purification by affinity, ion-exchange or other chromatographic methods from hybridoma and recombinant expression
• Perform antibody characterization (SDS-PAGE and SDS-cGE, SEC-HPLC, SEC-MALS) for quality control and support develop ability assessment of antibodies for stability, purity and other relevant biophysical properties
• Explore, enable, and execute the development of automated high throughput processes to support antibody production workflows on Bravo, and other platforms
• Develop expression and purifications methods for antibodies, difficult-to-handle proteins and optimize platform processes for higher production yields and product stability, including VLP production
• Develop a strong understanding of current protein chemical conjugation techniques, and work to optimize and validate them for research applications
• Effectively maintain meticulous records of lab activities using electronic notebook (Benchling); communicate findings clearly through written reports and presentations to support project progression and scientific decision-making
• Manage multiple projects independently demonstrating strong self-motivation, effective time management, and the ability to consistently meet project deadlines
• Demonstrate attention to detail and scientific judgment essential for guiding data-driven decisions
• Drive innovation and project success by providing creative solutions to protein science challenges, taking initiative to explore new ideas and approaches while collaborating effectively within the team and cross-functionally in a fast-paced research environment

• Ph.D. in Biochemistry, Chemistry, Molecular Biology, Protein Engineering, or a related field with a minimum of 1-3 years of industry experience or MS with minimum of 5-7 years of direct industry experience is required
• Proven hands-on experience with multiple mammalian expression platforms is required
• Proficiency with AKTA instrumentation, demonstrating a broad range of standard and unique antibody purification (e.g., affinity, ion exchange, HIC and SEC) and QC techniques is required
• Demonstrated track record of generating high-quality recombinant proteins for…