Scientist II

HD Biosciences Inc., a WuXi App Tec company, offers biology-focused preclinical drug discovery services to biotech and pharmaceutical clients. We offer our clients comprehensive service platforms around target validation, plate-based pharmacology, hit identification and lead discovery, in vivo pharmacology, as well as other research and development services.

We are seeking an initiative-taking and skilled scientist to join our fast-growing bioanalysis team. The position will independently design, execute, trouble shoot and deliver the projects with LC-MS (liquid chromatography – mass spectrometry), prioritizing large molecules such as biologics, peptides, ADCs (antibody drug conjugates), LNPs (lipid nanoparticles), and oligos, and including small molecule modalities when necessary.

• This is a laboratory-based role. Hands-on bench work is required
• Provides scientific and operational support for bioanalysis group
• Actively contributes and applies expertise and knowledge to collaborations with partners in the design and execution of related studies
• Contributes to project proposal preparation
• Leads ongoing projects to meet expected timelines
• Contributes for new capability implementation and team building
• Contributes to the overall operations and to the achievement of departmental goals
• Communicates with clients for designing, analysis, reporting and recording activities
• Performs job specific tasks in compliance with applicable Regulations, International Standards, WuXi App Tec Policies and Standard Operating Procedures
• PhD with 4+ years of relevant industry experience, MS with 7+ years of experience in Bioanalysis and Mass Spectrometry, and/or related field
• Strong scientific knowledge and hands-on technical expertise in LC-MS-based bioanalysis and drug discovery workflows. Industry experience in a CRO environment is highly desirable
• Demonstrated experience supporting ADC, biologic, LNP, small-molecule and/or oligonucleotide programs is strongly preferred.
• Technical expertise:
• Solid understanding of qualitative and quantitative LC-MS workflows for ADCs, LNPs, peptides/proteins, biologics, small molecules, including associated sample preparation techniques
• Strong competency with a broad range of LC-MS instrumentation, including triple quadrupole (QQQ), QTOF, and Orbitrap platforms
• Hands‑on experience with LC-MS method development, optimization, troubleshooting
• Experience developing and executing ADC bioanalytical assays, including characterization and/or quantification of ADCs, antibody/antibody‑drug conjugate components, payloads, metabolites and relevant catabolites
• Experience with LNP analysis by LC-MS, including characterization and/or quantitative analysis of LNP‑associated components, lipid components, payloads or related analytes
• Experience with DMPK and bioanalysis, including quantitative analysis of drug candidates and metabolites in biological matrices
• Strong experience with sample preparation from tissues, cells, plasma/serum, and other biofluids
• Proficiency with relevant data analysis and bioinformatics software, such as Skyline
• Prior experience with in vitro assays and/or ex vivo pharmacology studies supporting drug discovery programs is a plus
• Willingness and ability to lead or support studies beyond the LC-MS area, including cross‑functional projects and drug discovery activities as needed

• Demonstrated time management and multi‑tasking skills, ability to effectively prioritize workload and manage changes in direction
• Demonstrated ability for attention to details and concern for impact
• Effective communication skills with the ability to give and receive feedback, both verbally and in writing
• Ability to work in a team environment and independently as…