Scientist I or II in Medicinal Chemistry

Scientist I or II in Medicinal Chemistry

• Organic Synthesis
• Nucleosides and Nucleotides
• Conjugation

OliX Pharmaceuticals develops RNA interference (RNAi) therapeutics. Our San Diego chemistry team supports this work by developing molecular building blocks and conjugation approaches for siRNA medicines.

OliX US is seeking a Scientist I/II in Medicinal Chemistry with strong expertise in synthetic organic chemistry. In this laboratory role, you will design, synthesize, purify, and characterize small molecules, nucleosides, nucleotides, and conjugation partners that support our RNAi research.

The role offers the opportunity to solve challenging synthetic problems and connect your chemistry to the development of RNA therapeutics. You will work with colleagues in oligonucleotide chemistry and biology to develop compounds and conjugates, interpret results, and plan the next synthesis round.

• Design and execute multistep syntheses of small molecules, modified nucleosides and nucleotides, linkers, and conjugation partners.
• Develop and optimize synthetic routes, protecting-group strategies, reaction conditions, and purification methods to obtain well-characterized compounds.
• Develop and perform conjugation reactions linking oligonucleotides with small molecules, delivery ligands, or peptides.
• Confirm compound identity and purity using NMR, LC-MS, and HPLC/UHPLC; interpret analytical data and troubleshoot synthesis and purification challenges.
• Collaborate with oligonucleotide chemistry and biology colleagues to evaluate results and guide compound design and synthesis priorities.
• Maintain clear experimental records and prepare technical reports, presentations, SOPs, and batch records as appropriate.
• Contribute to laboratory safety and the operation, maintenance, and troubleshooting of relevant instruments.

• Ph.D. in Organic Chemistry, Medicinal Chemistry, or a related field with 0-3 years of postdoctoral or industry experience; or an M.S. with 5+ years of relevant industry experience in small-molecule synthesis.
• Strong practical experience in synthetic organic chemistry, including retrosynthetic analysis, multistep synthesis, reaction optimization, and purification.
• Ability to work independently at the bench, solve synthetic problems, and assess compound identity and purity using NMR and chromatographic methods.
• Clear scientific communication, careful record-keeping, and a collaborative research approach.

Appointment at Scientist I or Scientist II will depend on relevant experience and qualifications.

• Nucleoside or nucleotide synthesis, including protecting-group chemistry and modified building blocks for oligonucleotide synthesis.
• Bioconjugation, linker design, or synthesis of ligands used in oligonucleotide delivery.
• Application of structure-activity relationships or physicochemical property considerations to compound design.
• Preparation of SOPs, batch records, or reproducible procedures for scale-up or transfer.

Apply your organic synthesis expertise to the chemistry behind RNA medicines. This role combines small-molecule and nucleoside chemistry with conjugation, giving you opportunities to broaden your scientific experience while contributing directly to a collaborative research team.

• Medical, dental, and vision insurance
• Paid year-end company shutdown and holiday time off