Senior Scientist-R&D Oligo Synthesis

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Would you like to join an international team working to improve the future of healthcare? Do you want to enhance the lives of millions of people? Grifols is a global healthcare company that since 1909 has been working to improve the health and well-being of people around the world. We are leaders in plasma-derived medicines and transfusion medicine and develop, produce and market innovative medicines, solutions and services in more than 110 countries and regions.

Grifols Diagnostic Solutions in San Diego is seeking a highly skilled and motivated Scientist who is passionate about utilizing their expertise in oligonucleotide chemistry to provide oligonucleotide synthesis, purification, and analysis for R&D projects. The candidate will be responsible for a significant portion of a complex project or an entire less complex project or multiple less complex projects. The ideal candidate should understand the scope of the overall project in the scope of corporate strategy.

They may manage 1 or more personnel and may represent R&D on a Core Team for a product development project.

This position will require automated synthesis of oligonucleotides, purification of oligonucleotides by chromatographic techniques and characterization of oligonucleotides by a variety of physicochemical techniques and conjugation of oligonucleotides by a variety of methods. The candidate may also participate in basic research projects exploiting novel properties of oligonucleotides in R&D assays. The candidate is expected to present work internally or at scientific conferences or write scientific papers.

They are required to collaborate and communicate effectively with junior level employees, peers and cross-functional teams across all levels of the organization.

• Perform automated oligonucleotide synthesis, deprotection and purification via standard phosphonamidite chemistry and chromatographic purification techniques.
• Conduct oligonucleotide analysis using LCMS, MALDI, UV/VIS, and HPLC/UPLC techniques. Evaluate and identify impurities, degradation products, and synthesis by-products. Establish analytical protocols and support implementation of these protocols.
• Lead and execute complex experiments, including providing guidance and direction on experimental design, analysis and interpretation of data, communication of results, and design of follow-up experiments. Responsible for subproject or project goals and deliverables.
• Interact with peers and supervisors, both within the team as well as with other teams, to provide experimental summaries, design input, and ancillary team functions.
• Maintain clearly written experimental records in both written and electronic formats.
• Familiar with standard software tools utilized in instrument control, data analysis, and reporting results.

• Manage Execution:
  Conveys clear expectations for assignments, delegates enough of own work to others, monitors progress of others and redirects efforts when goals are not being met, continually looks for ways to improve processes, products, and/or services
• Build Realistic Plans:
  Develops realistic plans, actions steps and timetables for projects and assignments; identifies specific action steps and accountabilities, prepares realistic estimates of budget, staff and other resources
• Promote Teamwork:
  Promotes teamwork amongst groups:
  Discourages “we versus they” thinking, facilitates the discussion and resolution of different views; involves others in shaping plans and decisions that affect them; contributes to the efforts of the team’s work
• Share the Vision:
  Executes plans and develops strategies for achieving vision;
  Articulates the…