Proteomics Specialist

Sanford Burnham Prebys is much more than a research facility and hub for innovation; it’s a vibrant global community of talented scientists and researchers from over 30 countries. This worldwide representation enriches our perspectives and enhances our creative approach to solving complex scientific challenges.

We strive to be leaders not only in biomedical research but also in creating an environment where excellence thrives through collaboration across cultures and backgrounds. Our mission is to advance the biomedical sciences by cultivating the next generation of scientific leaders, providing meaningful opportunities for researchers of all backgrounds to learn, innovate, and make breakthrough discoveries that improve human health.

Together, we translate science into health.

The duties and responsibilities contained in the job description are intended to be examples of the accountabilities for which the person in the position will demonstrate competency through performance. The job description is not intended to be an all‑inclusive list. Duties and responsibilities are subject to change and other duties may be assigned as necessary.

The Proteomics Specialist is an early‑career scientific professional who supports the delivery of high‑quality proteomics services to investigators and research teams. Under the direction of the Proteomics Core Director and in collaboration with Core staff, the Specialist performs biological sample preparation, liquid chromatography–mass spectrometry (LC-MS/MS) analyses, proteomics data processing, quality assessment, and results reporting.

The Specialist supports multiple projects involving diverse biological samples and experimental objectives. Responsibilities include following established protocols, operating and maintaining laboratory and mass spectrometry instrumentation, troubleshooting routine technical issues, documenting project activities, and communicating results to Core users. The position also contributes to the implementation and optimization of established and emerging workflows, including discovery, quantitative, and targeted proteomics.

The primary focus of this position is to deliver reliable, reproducible, and responsive proteomics services while developing technical expertise in sample preparation, instrumentation, data analysis, and user support. Opportunities may include contributing to method development, technology evaluation, standard operating procedures, presentations, publications, and collaborative scientific projects.

• Work with the Core Director and Core staff to understand project objectives, sample requirements, timelines, and appropriate proteomics workflows.
• Assist with experimental planning and provide routine technical guidance to Core users under appropriate supervision.
• Organize and execute multiple proteomics projects according to established priorities, protocols, and deadlines.
• Prepare biological samples for proteomic analysis, including protein extraction, reduction and alkylation, enzymatic digestion, in-solution or in-gel processing, desalting, cleanup, fractionation, and enrichment.
• Operate automated sample‑preparation equipment, liquid chromatography systems, and high‑resolution mass spectrometers following established SOPs and training requirements.
• Perform LC‑MS/MS data acquisition for discovery, quantitative, and targeted proteomics applications, including DDA, DIA, PRM, SRM, label‑free quantification, and isobaric labeling workflows as applicable.
• Perform routine instrument checks, calibration, quality‑control assessments, and preventive maintenance.
• Monitor system suitability and data‑quality metrics, identify routine performance issues, and communicate or elevate…