Principal Scientist, Molecular Modeling/Peptide Design
Listed on 2026-02-15
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Science
Research Scientist
The Role
The Principal Scientist will design modern oral peptides including ncAA such as D-peptides, driving structure-activity relationships (SAR) from hit identification through clinical candidate nomination. Using molecular modeling and computational tools and experimental data, you will advance early hits by optimizing novel ncAA peptides with drug-like properties, while collaborating across a multidisciplinary team to translate scientific discoveries into transformative medicines. We are looking for an outstanding Molecular Modeller with strong peptide/medicinal chemistry skills or an outstanding Peptide/Medicinal Chemist with strong Molecular Modeling skills.
OurIdeal Candidate
You are passionate about the company's mission and a self-starter with an inextinguishable fire to compete and succeed. You thrive in an environment that requires crisp judgment, pragmatic decision-making, rapid course-corrections, and comfort with market ambiguity. You discharge your duties within a culture of mutual team respect, high performance, humility, and humor.
Key responsibilities- Lead the design and optimization of peptide hits to establish robust SAR and advance drug discovery programs to achieve sub-nanomolar (
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