Principal Scientist

Overview

WuXi Biology at San Diego, a division of WuXi App Tec Company, is seeking a highly motivated and established Principal Scientist with deep and broad expertise in Immunology drug discovery and research. The Principal Scientist will lead a group of junior scientists at the San Diego site to provide scientific services and solutions to our customers’ drug discovery research needs.

• Manages and leads a group of junior scientists in In Vitro Immunology team to execute a variety of scientific projects to ensure successful execution of projects and best quality services.
• Leads from the bench, builds and grows a high-performance team, provides effective mentorship and coordinates collaborations with colleagues from the same team and other cross-functional teams.
• Establishes and ensures delivery of financial and productivity goals.
• Provides innovative scientific proposals, identifies and implements emerging key technologies to expand service capabilities and fulfill customer needs in cutting‑edge drug discoveries.
• Responsible for drafting scientific proposals to provide solutions tailored to Client’s needs.
• Responsible for coordinating efforts and facilitating communication to ensure alignment between different units and our customers.
• Provides support and participates in business development activities to promote services and engage new customers.
• Ensures operation compliance of EHS rules and government regulations for all members of the in vitro Biology team.
• Perform job specific tasks in compliance with applicable Regulations, International Standards, and WuXi App Tec Policies and Standard Operating Procedures.
• Other duties as assigned.
• May be required to assist in other departments.

Experience / Education

Ph.D in immunology, molecular biology or related field with a minimum of 6 years of Biotech/Pharmaceutical/CRO working experience. Experienced with in vitro cell-based assays and scientific proposal/report writing.

Knowledge / Skills / Abilities:

• Demonstrated broad expertise in immunology.
• In-depth knowledge and hand‑on experience in vitro disease‑relevant models, including using human whole blood, PBMC, and isolated immune cell subsets, for autoimmune disease research and drug discovery.
• Have a mindset from in vitro, to in vivo and clinical translation to continuously improve the data translatability during in vitro assay development.
• Knowledge of in vitro pharmacology assay development, validation and compound screening for different drug modalities, such as small molecule inhibitor/modulator, mAb, depleting mAb, bispecific, multi‑specific, antibody‑oligonucleotide conjugate, antibody‑drug conjugate, antibody‑conjugated nanoparticles with various payloads (small molecules, peptides, hormones, and various RNA moieties).
• Experienced in managing team(s) to include junior scientists and research associates. Demonstrated ability to guide groups through team change and growth.
• Strong communication skills with collaborators and clients, and the ability to present information clearly and professionally to varying levels of individuals.
• Ability to work effectively in team settings, build collaborative relationships with customers, managements, and peers from diverse backgrounds.
• Thorough understanding of Good Laboratory Practices and Good Manufacturing Practices.

• Must be able to work in an office environment with minimal noise conditions.
• Must be able to work in Lab setting with exposure to Animals/biohazards / Chemicals (List specific Chemicals).
• Must not have animal allergies to applicable species in this facility.
• Must be able to wear appropriate PPE.
• Must be able to work in environment with variable noise levels.
• Ability to stand /Sit/walk for long periods of time.
• Ability to lift 10 lbs routinely.
• Ability to crouch, bend, twist, and reach.
• Ability to push/pull 10 lbs routinely/ often / occasionally.
• Clarity of Vision.
• Ability to identify and distinguish colors.
• Must be able to perform activities with repetitive motions.
• Ability to climb Ladders / Stairs / Scaffolding.
• Ability to work in variable temperatures high to freezing.
• Inside/outside working conditions.

Anticipated base pay range: $128,552 to $167,239

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin or protected veteran status and will not be discriminated against on the basis of disability.

This job description does not state or imply that the above are the only duties and responsibilities assigned to this position. Employees holding this position will be required to perform any other job‑related duties as requested by Management.