Biochemist - Conjugation

Overview

Bio Legend is looking for a Biochemist II who will be responsible for performing antibody–fluorophore conjugations from small-scale development batches to large-scale production lots. This role requires strong technical proficiency in conjugation chemistry, consistent execution, excellent documentation practices, and active participation in continuous improvement initiatives. As manufacturing evolves toward increased automation and digital capabilities, the Biochemist II is also expected to be comfortable working with automated systems, electronic tools, and data-driven workflows to support future-ready operations.

• Perform antibody–dye conjugations across scales; protect light-sensitive fluorophores during reaction and purification
• Purify conjugates via SEC, desalting, and/or affinity chromatography
• Calculate concentrations, D/P ratios, yields, and other key quality metrics
• Drive yield and passing rate improvements
• Operate, maintain, and troubleshoot lab equipment
• Support semi-automated instrumentation and electronic batch records
• Support adoption of automation and AI-enabled tools that enhance accuracy and efficiency
• Review, verify, and update SOPs, batch records, and compliance documentation
• Participate in troubleshooting, root-cause investigations, and continuous improvement and lab safety initiatives
• Provide training to team members
• Other projects or responsibilities may be required.

• Bachelor’s degree in Biochemistry, Chemistry, or related field
• ≥ 2 years of independent, hands-on experience performing high-quality antibody–dye conjugation reactions

• Strong understanding of conjugation chemistry and purification techniques
• Experience handling light-sensitive fluorophores during reaction and purification while maintaining product integrity
• Experience with multiple conjugation chemistries
• Exposure to automation, SEC, and electronic batch records
• Experience working in an ISO/GMP manufacturing environment

Applicants must be currently authorized to work in the United States on a full-time basis for any employer.

Lab – The employee regularly works in a laboratory environment with occasional data entry on a computer. Occasional exposure to a warehouse environment. The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. The employee is regularly required to use hands and fingers to handle, feel, or operate objects, tools or controls, and reach with hands and arms.

The employee is frequently required to stand, talk and hear.

The base salary range for this full-time position is $20.50 - 28.00/hr this range reflects the minimum and maximum target for a new hire in this position. The base pay actually offered to the successful candidate will take into account internal equity, work location, and additional factors, including job-related skills, experience, and relevant education or training. Your recruiter can share more about the specific salary range for your preferred location during the hiring process.

Please note that base pay is only one part of our total compensation package and is determined within a range. This range allows for the successful candidate to have an opportunity to progress within the position and develop at our company. This base pay range does not take into account bonuses, equity, or other benefits which may be applicable and are dependent on the level and position offered.

• Medical, Dental, and Vision Insurance Options
• Life and Disability Insurance
• Paid Time-Off
• Parental Benefits
• Compassionate Care Leave
• 401k with Company Match
• Employee Stock Purchase Plan