Throughput Biology Principal Research Associate

Job Description

Vertex Pharmaceuticals, Inc. is seeking a highly skilled and proactive Principal Research Associate to join our Human Cell Core, contributing to the development and execution of advanced human cell models  ideal candidate is an expert experimentalist who excels in a fast-paced, team-oriented environment and operates with a high level of scientific rigor and independence.

This role involves maintaining and expanding primary human cells at scale, operating automation-enabled cell culture platforms and executing functional assays to support cell optimization and troubleshooting efforts. Success in this position requires exceptional reliability, attention to detail, adaptability, problem‑solving skills and ability to work in a team-oriented environment.

• Maintain and expand primary human cells at scale, ensuring batch reliability and consistency across multi‑week workflows.
• Operate, optimize, and troubleshoot state‑of‑the‑art instrumentation and liquid handling equipment to support human cells at scale.
• Conduct complex, rigorous experiments independently to answer critical questions.
• Evaluate emerging technologies and methods and implement improvements that enhance throughput, robustness, or reproducibility.
• Execute functional assays and interpret data to support optimization, cell validation and troubleshooting efforts.
• Maintain high‑quality, detailed digital records of methods, results, and system performance.
• Present experimental findings at internal project team meetings, contributing data‑driven recommendations to inform next step decisions.
• Communicate effectively in team meetings, cross‑functional settings, and written reports.

• Demonstrated expertise in culturing primary human cells or iPSCs.
• Hands‑on experience operating and troubleshooting laboratory automation instrumentation.
• Strong understanding of QC metrics, cell characterization workflows, and high‑throughput assay principles.
• Proven ability to work independently while contributing to a collaborative team environment.
• Excellent organizational and communication skills.
• Exceptional multitasking skills, attention to details and ability to work in a collaborative team environment.
• Ability and willingness to work rotating weekend shifts according to business needs.

• Master’s Degree (or equivalent degree) in biological sciences and 0‑2 years of relevant employment experience, or
• Bachelor’s Degree (or equivalent degree) in biological sciences and 5+ years of relevant employment experience.

$88,000 – $132,000

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job‑related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market‑leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week‑long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

On‑Site Designated

In this On‑Site designated role, you will work five days per week on‑site with ad hoc flexibility.

Note:

The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at A