Senior Scientist - Protein Engineering

Working with Us

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.

Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

We are seeking an enthusiastic, creative, and versatile Senior Scientist to join our collaborative Protein Engineering team to drive technological innovation, discover and engineer innovative biotherapeutic candidates. Our group acts on new ideas in the laboratory and thrives on the design-build-test cycle. You will solve complex protein engineering problems, develop new skills, and use them to implement robust platforms for protein therapeutic optimization.

You will collaborate with talented colleagues and share what you learn. You will present at internal and external meetings, contribute to therapeutic pipeline projects, publications, and patents. Responsibilities include selection-based assays using protein display library technologies, binder engineering for antibody-target interaction, cross-function and cross-site collaboration and project management.

Responsibilities

* Drive efforts to engineer antibodies, multispecifics, and alternative biologics formats for optimal therapeutic performance

* Selections on yeast display libraries, routine operation and maintenance of a sorter

* Library design in collaboration with AI/ML engineers, library construction, NGS

* Independently perform routine molecular biology techniques, DNA assembly and cloning, design expression constructs for external synthesis, and coordinate construct and library orders with CROs

* Analyze library NGS data using no-code or low-code bioinformatics platforms

* Independently perform complex experiments, troubleshoot, expertly analyze and interpret experimental results with strong attention to detail and documentation practices

* Present results internally and externally, attend industry conferences

* Accomplish goals under project team timelines

Basic Qualifications

* Bachelor's Degree with 7+ years of academic or industry experience

OR

* Master's Degree with 5+ years of academic or industry experience or

OR

* PhD in Biochemistry, Bioengineering, Molecular Biology, or related fields with 2+ years of academic or industry experience

Preferred Qualifications

* PhD in Biochemistry, Bioengineering, Molecular Biology, or related fields with 2+ years of relevant post-graduate or biotech/biopharma industry experience

* Experience with molecular and microbiology techniques underlying yeast display work

* In-depth understanding…