Senior Scientist - Analytical Chemistry, Purification

Role Overview

We are seeking an experienced analytical chemist to own, develop, and run Satomic's chromatography-based purification fleet with both SFC-MS and LC-MS instrumentation for detection and fraction collection. This role is central to Satomic's mission: purification is a bottleneck and our throughput targets demand a fleet that runs as a coordinated, automation-friendly system built for throughput rather than as individual instruments.

We are hiring on demonstrated depth in high-throughput reversed-phase LC-MS purification. Hands-on SFC experience is an advantage. The successful candidate will develop, optimize, and standardize high-throughput, mass-directed purification methods and workflows, from fraction collection logic through post-purification data and sample handling. The work centers on SFC and LC purification to deliver high-quality compounds and data that accelerate drug discovery efforts. You will keep the fleet running through preventive maintenance and fast troubleshooting, and partner closely with our software and automation teams to scale the purification capabilities.

This is a hands-on, lab-based position for a candidate who thrives in high-throughput environments and is motivated to develop purification methodologies that are robust, scalable, and innovative while prioritizing rigorous data quality standards and sample integrity.

• Fully onboarded to all company policies, lab operations, and safety protocols
• Achieved proficiency operating the reverse-phase LC fleet, running both analytical and preparative methods independently.
• Begun structured training on preparative and analytical SFC systems and built a working understanding of CO2 delivery, back pressure regulation, and modifier selection.
• Mapped the current end-to-end purification workflow (sample submission -> method selection -> run -> fraction collection -> analysis -> evaporation -> consolidation -> reporting) and identified the top 3 throughput bottlenecks
• Begun running routine purifications and contributing to the standing sample queue

• Sustained throughput of >=50 samples per instrument per day on at least one preparative SFC or one preparative LC system, with documented purity and recovery metrics
• Developed and validated a standardized method set (generic gradients, column selections, modifier choices) that covers >=80% of small-molecule samples without per-sample method development
• Reached fluency in independent operation of the preparative SFC fleet for routine purifications.
• Authored standard operating procedures for instrument operation, fraction collection logic, and routine maintenance for each instrument class
• Designed and tested partner-facing post-purification QC methods for outgoing products
• Partnered with the software/automation team to integrate purification data flow with Analytical Studio (or equivalent) for automated submission, tracking, and reporting
• Established minimum evaporation times for varying volumes of collected fractions from LC and SFC purifications, enabling process optimization
• Defined fraction consolidation logic, taking into consideration tradeoffs between purity, yield, and transfer process logistics

• Achieved sustained fleet-wide throughput of ~96 samples per instrument per day across all 6 preparative systems, with >=90% scheduled uptime
• Built and deployed an automated purification workflow (queue management, automated fraction analysis, and structured data handoff); identified and integrated further automation that minimizes hands-on work per sample beyond submission
• Reduced average purification turnaround time (sample submitted -> purified compound delivered) by a measurable amount versus the 90-day baseline, with results quantified and reported
• Established a maintenance and consumables program (columns, seals, pumps, frits, ESI sources) that prevents/shortens the majority of unplanned downtime events
• Optimized evaporation and sample consolidation process, maintaining evaporator uptime >80%
• Influenced capital equipment decisions as instrumentation needs grow.

• Established…