Purification Scientist; Chemistry

Job Title

Our large pharmaceutical client in La Jolla, CA is seeking a highly motivated BS- or MS-level chemist with small molecule purification skills to advance drug discovery programs toward the clinic.

A minimum of a bachelor's degree in Analytical, Synthetic, Organic, Medicinal Chemistry or related Chemistry degree
-Minimum of 2 years small molecule purification and mass spectrometry experience
-HPLC or SFC chromatography experience

Knowledge of LCMS and molecular properties
-Knowledge of NMR

- Experience with Waters/Agilent equipment
-TECAN or other liquid handlers for lab automation

In this laboratory-based position, the successful candidate will perform high throughput purification of small molecule pharmaceuticals synthesized by medicinal chemists. This includes the purification of compounds from focused chemical libraries or singleton samples with mass-directed Super Fluid Chromatography (SFC) or High Performance Liquid Chromatography (HPLC). She/he will maintain close interactions with scientists from Discovery Chemistry, Discovery Process Chemistry and Parallel Medicinal Chemistry teams to expedite the compound design-synthesis-test iterations.

Strong people skills and the ability to thrive in a team and goal driven environment are key attributes.

Additional Responsibilities:

-Conduct daily system suitability check on SFC-MS and LC-MS instrumentation
-Maintain instruments in good working condition and perform troubleshooting analysis and maintenance as required
-Assist with preliminary screening experiments prior to sample purification and post purification sample downstream handling
-Assist with chiral characterization of small molecules
-Conduct ad hoc large scale (grams) purification work for small molecules
-Support lab operations and maintain general lab orderliness
-Assist in the maintenance of a safe working environment and operate in a safe manner
-Other duties and assignments as needed to support the lab operations