Senior Scientist , Computational Biology; targetID

HAYA Therapeutics is a precision therapeutics company based at the life sciences park Biopôle SA in Lausanne, Switzerland, and JLABS, San Diego, USA. Haya Therapeutics is developing novel tissue-specific antisense oligonucleotide drugs targeting long noncoding RNAs in fibrotic diseases including heart, lungs, kidney, liver, and cancers.

Execute Target Discovery and Validationactivities  withinthe Data Science teamtoidentifyandvalidatecell-state drivingdisease-modifyinglncRNAsand regulatory elements by integratingmulti-omicstranscriptomics and epigenomicsdatasets, withmain focusonimmunology and inflammatory indications

• Preprocess and analyzeraw multi-omics datasets (including bulk/single-cell/single-nuclei RNA-seq, ATAC-seq, PRO-seq, CUT&RUN, 3D genomics) to characterize the regulatory genome driving cell states and extract the features to performtarget identification.

• Integrate human genomic, genetic, and epigenetic datasets (including GWAS,eQTLs, and chromatin conformation annotations) with internal transcriptomic pipelinestoidentifypotent cell-state drivinglncRNA targets.

• Translate high-dimensional omicsanalysis and results into clear, biologically grounded scientific presentations and documentationtofacilitatestrategicalignment, influence multi-disciplinary program stakeholders, and support executive decisions.

• PhD in Computational Biology, Bioinformatics, Computer Science, Genomics, or a related quantitative or life sciences field with a robust computational focus; or equivalent demonstrated capability and technical depth.

• Proficient programming skills in R or Python, supported by strong data hygiene, and a desire to build sharedreproducibletoolkitsand pipelines.

• Experience onthe identification ofnoveltargets,demonstratinga strong drive to design andleveragecomputational workflows with minimal supervision.

• Deep technicalproficiencyin preprocessing, integrating, and analyzing multi-omics datasets, specifically bulk and single-cell/single-nuclei RNA-seq, ATAC-seq, PRO-seq, and CUT&RUN, to definecellstates andidentifybiological drivers within the regulatory genome.

• Excellent scientific understanding of gene regulation, transcriptomics, and the non-coding genome (in particularlncRNAs) andgene regulatory networks.

• Proven capability in presenting complex multi-omicsstatistical analyses, and data science concepts in a clear, narrative-driven manner to both technical, biological, and non-expert stakeholders, serving as a bridge between dry and wet lab activities.

• Biologicalexpertisein immunology, inflammatory indications, or immune cell profiling, with the ability to contextualize transcriptomic discoveries in the frame of chronic pathology (highly desired).

• Work within scalable server and cloud automation standards,write reproducible scripting templates, andkeepsdata scienceanalysisstandardsthat raise the technological bar for the entire Data Science & AI department.

• Demonstrated history of fostering a collaborative scientific culture by providing code reviews, guiding junior analysts on data science best practices, and ensuring strict adherence to reproducible computational biology.

HAYA Therapeutics is an Equal Opportunity Employer committed to fostering a diverse, inclusive, and equitable workplace where all individuals feel valued and empowered. We provide equal employment opportunities to all qualified applicants and employees without regard to race, color, religion, sex (including pregnancy, sexual orientation, gender identity, or gender expression), national origin, ancestry, age, marital or familial status, veteran status, disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws.

We prohibit discrimination and harassment of any kind and are committed to ensuring fair and equitable treatment in all aspects of recruitment, hiring, promotion, compensation, benefits, training, and career development. At HAYA, we believe that diversity of thought, experience, and background drives innovation and strengthens our mission to transform patient care through cutting-edge RNA-based therapeutics.

HAYA Therapeutics operates a Preferred Supplier List (PSL) and manages all recruitment directly through our Human Resources team. We do not accept…