Principal Bioinformatics Scientist

Research & Development (R&D)

At Veracyte, we offer exciting career opportunities for those interested in joining a pioneering team that is committed to transforming cancer care for patients across the globe. Working at Veracyte enables our employees to not only make a meaningful impact on the lives of patients, but to also learn and grow within a purpose driven environment. This is what we call the Veracyte way– it’s about how we work together, guided by our values, to give clinicians the insights they need to help patients make life-changing decisions.

Our Values:

• We Seek A Better Way
  :
  We pursue bold ideas, embrace complexity, and keep pushing forward.
• We Make It Happen
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  We act with urgency, deliver with excellence, and always find a way.
• We Are Stronger Together
  :
  We engage with empathy, align around what's best for Veracyte, and celebrate as one team.
• We Care Deeply
  :
  We show up with integrity, kindness, and respect for one another.

Job Description:

We are seeking a highly experienced and motivated Principal Bioinformatics Scientist to lead the bioinformatics strategy, design, and development of next-generation minimal residual disease (MRD) laboratory-developed tests (LDTs). This role is a senior technical leadership position responsible for shaping assay concepts, driving analytical development and validation, and partnering closely with wet-lab, clinical, quality, regulatory, and software teams to deliver robust, clinically actionable MRD diagnostics for multiple indications.

The ideal candidate brings deep expertise in NGS-based oncology assays, strong understanding of ctDNA biology and a proven track record of industry assay development under design control. This individual will serve as a scientific and technical leader, owning assay bioinformatics from concept through analytical validation and launch.

KEY RESPONSIBILITIES:

Scientific & Technical Leadership

• Lead bioinformatics strategy for MRD assay design, development, optimization, and lifecycle management for LDTs developed under CAP/CLIA quality systems.
• Serve as the bioinformatics owner, driving study design, data analysis, performance characterization, and decision-making throughout development.
• Apply deep domain knowledge in cancer genomics, ctDNA biology, and NGS technologies to inform assay architecture, variant detection strategies, and error suppression approaches.

Assay Development & Validation

• Design and execute analytical studies to evaluate assay performance, including accuracy, limit of detection, and reproducibility, in collaboration with wet-lab and biostatistics partners.
• Develop, validate, and maintain scalable, production-ready bioinformatics pipelines for MRD analysis, including QC, variant calling, MRD calling logic, and reporting.
• Lead benchmarking and optimization of computational methods, including background error modeling, and longitudinal MRD tracking.
• Ensure compliance with standards (CAP/CLIA, FDA, IVDR) throughout the bioinformatics development lifecycle, including rigorous testing and documentation.

Cross-Functional Collaboration

• Partner closely with molecular biology, assay development, QA/RA, clinical, and software engineering teams to ensure bioinformatics solutions are aligned with assay design, regulatory expectations, and operational constraints.
• Facilitate successful production pipeline deployment by working closely with infrastructure and engineering teams
• Contribute to regulatory submissions and audits by providing technical documentation and validation report, and responses to audits or regulatory inquiries.
• Mentor junior scientists by providing technical and scientific guidance, helping raise the overall bar of assay development rigor and execution.
• Communicate complex analytical concepts and results…