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Senior Software Engineer; Primary Analysis

Job in San Diego, San Diego County, California, 92189, USA
Listing for: Illumina
Full Time position
Listed on 2026-02-28
Job specializations:
  • Software Development
    Software Engineer, Senior Developer, Machine Learning/ ML Engineer, AI Engineer
Salary/Wage Range or Industry Benchmark: 129400 - 194000 USD Yearly USD 129400.00 194000.00 YEAR
Job Description & How to Apply Below
Senior Software Engineer (Primary Analysis) page is loaded## Senior Software Engineer (Primary Analysis) locations:
US - California - San Diegotime type:
Full time posted on:
Posted Todayjob requisition :
42245-JOB## At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.## Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference.

Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.## We are searching for a software engineers who is ready to join us in this important mission. Illumina’s Primary Analysis team specializes in designing algorithms and developing software to detect genomic data from signals contained within images.  Implementation challenges include managing parallel tasks, optimizing memory accesses, and improving the speed and accuracy of genomic base calling.

We develop methods to address these challenges by focusing on high reliability, speed, and completeness of results.  We are seeking an exceptional individual to join our team in developing analysis solutions for use by researchers and clinicians worldwide.
** Responsibilities:
*** Define software architecture solutions for our high-performance signal processing pipelines
* Design, develop, debug, and integrate C/C++ software on Linux for multi-threaded applications
* Optimize and accelerate software executed on Illumina instruments
* Closely interact with the bioinformatics team, instrument design team, test and quality teams
* Collaborate in an agile environment to maintain high quality software against established processes
* Maintain awareness of industry trends and evaluate applicability of new software and hardware technologies to platform development efforts
* Provide technical leadership where needed
** Requirements:
*** Extensive knowledge and experience with C/C++, Java or C#
* Experience in multi-threading, and memory management techniques
* Proficient with tools for software debugging and troubleshooting (GDB, etc.)
* Proficient with tools for software performance analysis and optimization
* Proficient with source control management repositories (such as GIT, SVN, etc.)
* Extensive experience writing high quality unit tests against mock objects
* Good understanding of object-oriented analysis and design
* Strong problem-solving skills
** Desired:
*** Extensive knowledge and experience in developing software for real-time systems
* Experience with image processing algorithms and techniques  +

Experience with time-series analysis and interpretation of temporal data
* Experience with Python and Python visualization libraries
* Be customer-focused, team-oriented, and motivated, taking ownership of assigned tasks
* Have proven ability to self-manage, as well as manage interdisciplinary relationships
* Have proven verbal and written communication skills
*
* Education & Experience:

*** BS/MS in Computer Science, EE, Bioinformatics, or related field
* 5+ years of professional software development experience#LI-HYBRID### The estimated base salary range for the Senior Software Engineer (Primary Analysis) role based in the United States of America is: $129,400 - $194,000. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. Compensation decisions are dependent on several factors including, but not limited to, an individual’s qualifications, location where the role is to be performed, internal equity, and alignment with market data.

Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement…
Position Requirements
10+ Years work experience
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