Principal Administrative Business Partner – Rare Disease

The Position Why Genentech

We’re passionate about delivering on Our Promise to improve the lives of patients and create healthier communities for all. We foster a culture of inclusivity, integrity and creativity while boldly pursuing answers to the world’s most complex health challenges and transforming society.

As the Principal Administrative Business Partner for our Rare Disease (RD) Squads, supporting Rare Blood Disorders (RBD) and Neurological Rare Diseases (NRD), you will serve as a strategic operational anchor within U.S. Commercial, Medical, and Government Affairs (CMG). In this high-impact role, you provide executive administrative partnership to the RD Squad Leader, Chief of Staff, and broader squad teams driving commercialization strategies for life-changing therapies including HEMLIBRA, PIASKY, EVRYSDI, and ENSPRYNG.

You will balance autonomy, organizational savvy, and operational excellence while actively contributing to our vibrant Commercial Portfolio Organization (CPO) Operations and Administration Community.

• Proactively manage complex executive calendars across domestic and international time zones, exercising astute judgment to balance high-priority business demands, confidential matters, and stakeholder access.

• Partner closely with Squad Operations to design, organize, and execute operational cadences, including drafting rolling agendas, prepping executive materials, and leading large-scale offsites, national field meetings, and departmental workshops.

• Lead and implement internal engagement and communications strategies, drafting executive communications, overseeing digital collaboration hubs (gSites, newsletters), and maintaining team alignment.

• Serve as a central connector and project lead across cross-functional teams, managing vendor/speaker contracts, RFP processes, invoices, and purchase orders with rigorous resource sensitivity.

• Drive team operational health and culture by spearheading space planning initiatives, leading full-cycle onboarding logistics for new hires, and serving as a trusted thought partner on team engagement and pulse checks.

• Actively pilot and champion modern digital tools, workflows, and best practices across the CPO Administration community to foster a continuous learning and improvement environment.

• You bring an average of 5–10 years of related administrative, operations, or project management experience supporting senior leadership teams.

• You hold a proven track record of handling highly confidential and proprietary business information with the utmost discretion and integrity.

• You possess demonstrated mastery in independently prioritizing, planning, and executing complex workflows, large-scale events, and project initiatives across matrixed organizations.

• You demonstrate advanced fluency with enterprise productivity and collaboration tools (including Google Workspace, gMail, gCal, gSheets, gSlides, gMeet, as well as Zoom and digital site builders).

• You possess a Bachelor’s degree (BS/BA) or equivalent industry experience.

• Prior administrative or operational experience within the biotechnology or pharmaceutical industry.

• Previous experience navigating the Genentech or Roche enterprise network, culture, and matrixed operating models.

• Demonstrated experience training, mentoring, or instructing peers on productivity tools, systems, and standardized administrative processes.

• Background in supporting commercial, medical, or regulatory affairs squads within rare diseases or specialty therapeutic areas.

• This role is based in South San Francisco and offers a hybrid schedule working 3 day per week on campus

• No relocation benefits are available for this posting

The expected salary range for this position based on the…