Director, Transactions

Lakefront Biotherapeutics is a global biotech with offices in Belgium, Chicago and San Francisco, focused on building a differentiated immunology and inflammation pipeline to address serious diseases with high unmet medical need. Our pipeline is anchored by T‑cell engager programs, led by a potential first‑in‑class clinical asset and complemented by an exciting preclinical portfolio in autoimmune disease.

Our lead asset is being developed for severe immune‑mediated diseases, while additional preclinical programs expand the long‑term potential of our R&D pipeline. At Lakefront, we focus on advancing programs with strong biological rationale, clear clinical proof of concept and large commercial opportunities.

Are you ready to transform lives and be part of a journey like no other? We are building a company where science, execution, and accountability matter. Rather than layers of hierarchy, we operate with small, empowered teams that work hands‑on across development stages to move programs forward efficiently and thoughtfully.

We are looking for people who want to contribute directly, who are motivated by solving real problems, collaborating across disciplines, and taking ownership from idea to impact. At Lakefront, every role plays a part in shaping the future of medicines that have the potential to make a meaningful difference for patients.

If you are driven to improve the lives of patients, energized by execution, and excited to help build a growing company with a strong balance sheet, we look forward to meeting you.

AsDirector Transactions, you will play a key role in supporting the Chief Business Officer (CBO) and Vice President of Transactions in the execution of business development activities. Your focus will be onvaluation analysis, managing deal processes, and communicating updates to senior management and the Board of Directors. You will supervise and direct financial modeling to provide analytical rigor to support transaction decision-making.

You will be the hub for cross‑functional due diligence, draft term sheets and definitive agreements, and develop clear, compelling presentations. This role offers an opportunity to gain significant exposure to high‑profile deals in the biopharma sector, while collaborating with senior leadership and cross‑functional teams.

Our Business Development team is based in theSan Francisco Bay Area.

• Provide day‑to‑day support on transaction work streams under the leadership of the Vice President Transactions
• Develop and maintain complex financial models to evaluate companies, assets, partnerships, and transaction structures across multiple scenarios
• Conduct valuation and sensitivity analyses to inform deal strategy and recommendations
• Manage specific work streams within the transaction process, including due diligence coordination and information gathering
• Draft high‑quality presentations and supporting materials for internal stakeholders, including management committee and board reviews

• Work closely with cross‑functional teams to integrate inputs into financial models and transaction analyses
• Support the preparation of business cases and transaction documentation with analytical and strategic insights
• Partner with external advisors (bankers, consultants, lawyers) to ensure robust execution of deal processes

• 4-6 years of post-MBA experience in investment banking, private equity, or consulting, ideally with exposure to healthcare or biopharma transactions
• Strong technical skills in financial modeling, valuation, and analysis of company and asset-level economics
• Solid understanding of transaction processes, including due diligence, process management, deal structuring, and negotiation
• Excellent analytical and problem‑solving skills, with the ability to manage multiple priorities in a fast‑paced environment
• Strong communication and presentation skills, with the ability to convey complex analyses clearly to senior stakeholders
• Highly organized, detail-oriented, and proactive, with a collaborative mindset

We provide a competitive compensation and benefits package, along with a…