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Head of Security

Job in San Francisco, San Francisco County, California, 94199, USA
Listing for: Uncover
Full Time position
Listed on 2026-09-03
Job specializations:
  • IT/Tech
    Cybersecurity, Information Security & Data Protection, Security Management & Operations
Salary/Wage Range or Industry Benchmark: 250000 - 380000 USD Yearly USD 250000.00 380000.00 YEAR
Job Description & How to Apply Below

About Plenful Plenful is on a mission to transform healthcare operations from the inside out. Fresh off our $50M Series B and backed by Notable Capital, Bessemer Venture Partners, TQ Ventures, Susa/Kivu Ventures, and other leading investors, we’re building the category-defining AI workflow automation platform that healthcare teams rely on to operate smarter, faster, and more efficiently. Our technology empowers healthcare operators across hospital and health systems, pharmacies and payors to eliminate manual work, reduce administrative burden, and improve compliance, all while unlocking critical revenue to fund programs for their in-need patient populations.

Built by healthcare operators for healthcare operators, Plenful is driven by a deep understanding of the challenges facing today’s care teams. We’re passionate about equipping healthcare workers with world‑class tools that deliver real, measurable impact, and we’re proud to serve 90+ leading health systems across the country. If you’re excited to help shape the future of healthcare.

About the Role

Security is now a strategic differentiator for Plenful, and we're building the function from the ground up. As Head of Security, you'll own security across the company — product and application security, cloud infrastructure, corporate security, governance, compliance, and customer trust. You'll set the strategy, hire the team, and build the processes that let us scale securely without losing the speed of a high-growth startup.

You'll partner across Engineering, Product, IT, Legal, and Executive Leadership to embed security into everything we build. We're looking for a builder — someone who's comfortable in ambiguity, has stood up security programs from zero before, and wants to build an organization that scales with the business. In your first 12 months, you'll build and execute a company-wide security roadmap, stand up a high-performing security organization, mature our cloud, application, and corporate security capabilities, and strengthen the compliance and customer trust programs that support enterprise growth.

What

You'll Do
  • Build the Security Organization
  • Define and execute Plenful's long-term security strategy
  • Hire, mentor, and lead a high-performing security team
  • Establish the organizational structure, operating model, and roadmap for Security
  • Build processes that support rapid product development without slowing innovation
  • Serve as Plenful's security leader, internally and externally
Product & Application Security
  • Establish secure software development lifecycle (SSDLC) practices across Engineering
  • Integrate security into CI/CD pipelines and developer workflows
  • Lead threat modeling, secure architecture reviews, penetration testing, and vulnerability management
  • Define security standards for our AI-powered products and ML systems
Cloud & Infrastructure Security
  • Own cloud security strategy across our AWS infrastructure
  • Lead IAM, secrets management, endpoint security, infrastructure hardening, and network security
  • Build monitoring, detection, logging, and incident response capabilities
Governance, Risk & Compliance
  • Lead our security compliance strategy — SOC 2, HIPAA, HITRUST, and what comes next
  • Develop company-wide security policies, standards, and governance
  • Own vendor risk management and third-party security reviews
  • Partner with Legal and Compliance on security and privacy initiatives
Customer Trust & Executive Partnership
  • Represent Security in enterprise customer security reviews
  • Partner with Sales and Customer Success on enterprise deals and due diligence
  • Advise executive leadership and the Board on security posture, risk, and investment priorities
  • Build a security-first culture through education and partnership
Incident Response
  • Build and mature Plenful's incident response program
  • Lead investigations, postmortems, tabletop exercises, and business continuity planning
  • Continuously improve security monitoring and threat detection
You May Be a Fit If
  • You have 15+ years of progressive experience in cybersecurity, information security, cloud security, or infrastructure security
  • You have spent 5+ years leading security organizations at technology companies
  • You built and…
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