Director, Program Management

Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs.

Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date.

We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals;

and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.

We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the front lines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast‑paced environment.

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We are seeking an experienced Director of Program Management to join our dynamic team. This role will be critical in driving programs from discovery and development candidate nomination through clinical development, ensuring high-quality, decision-ready execution across research, preclinical, regulatory, and clinical functions.

In this role, you will provide end-to-end program management leadership, serving as the operational owner for assigned programs. You will be accountable for integrated program plans, timelines, risk management, and governance, and will partner closely with scientific and development leaders to align execution with company strategy. As the point of contact for program execution, you will proactively manage risks, facilitate trade‑off discussions, and enable informed decision‑making at both the team and executive levels.

This position reports to the Senior Director of Program and Portfolio Management and is a full‑time, onsite position requiring in‑person collaboration with cross‑functional teams.

• Lead program management for one or more development programs from preclinical development through clinical stages
• Partner with the cross‑functional Product Development Team to define program strategy, conduct scenario planning, and translate strategy into executable plans to achieve program objectives
• Identify and manage program‑level risks, assumptions, and interdependencies; lead mitigation planning and issue resolution
• Escalate risks and decision points with clear options and recommendations
• Work with teams to prepare presentations for internal and external meetings (e.g., team presentations, management review, Board of Directors meetings)

• Develop and maintain integrated program plans, including milestones, timelines, budgets, and resource assumptions
• Monitor progress against plans, identify deviations, and implement mitigation strategies or alternative scenarios
• Conduct critical path and dependency analyses to proactively identify risks and bottlenecks

• Ensure clear, consistent, and transparent communication of program…