Director, Externally Research

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.

As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

The Director, Externally Sponsored Research (ESR) (including investigator sponsored trials and collaborative research) will lead the strategy, oversight, and execution of Revolution Medicines' ESR processes within one of our disease areas. This role will ensure scientific rigor, compliance, and alignment of the ESR program with company and external regulatory guidelines. The individual will collaborate closely with internal and external stakeholders to drive excellence in external research.

Specifically, this individual will partner with Medical Strategy, Clinical Operations, and others on strategic development and execution of the program. The opportunity involves leadership of ESR-specific scientific committees and broad visibility within the organization. The Director, ESR, reports to the head of the ESR program.

Externally Sponsored Research Program Leadership

• Oversee the end-to-end ESR process for a specific disease area, including development of areas of interest, proposal review, approval, funding, and execution.
• Help set scientific and strategic objectives and ensure that ESRs align.
• Represent ESR program within the organization.
• Lead cross-functional scientific committees in proposal and protocol reviews.
• Maintain compliance with regulatory and legal requirements.
• Monitor ongoing ESRs progress, ensuring milestone tracking, study reporting, and data dissemination.
• Optimize ESR program scalability and operational efficiency, including systematic tracking of proposals, funding allocations, and study outcomes.
• Will directly supervise the ESR manager assigned to the program.

Cross-Functional & External Stakeholder Collaboration

• Serve as a key point of contact for ESR-related interactions with internal and external stakeholders.
• Partner with Clinical Operations on execution of the ESR program, including contracting, budgets, enrollment, and metrics.
• Work closely with Medical Affairs, Clinical Development, Preclinical, and other teams to align ESR funding with strategic priorities.
• Build relationships with external medical and scientific communities, including external investigators, KOLs, and cooperative groups.
• Ensure timely and transparent communication with investigators, maintaining strong external partnerships.

• Advanced scientific or medical degree (PhD, PharmD, MD).
• 10+ years of experience in Medical Affairs and ESRs within the biotechnology or pharmaceutical industry.
• Proven ability to develop and execute medical research strategies aligned with company and scientific priorities.
• Experience in ESR program leadership, including proposal review, funding allocation, and study execution.
• Ability to navigate cross-functional partnerships with Legal, Compliance, Regulatory, and Clinical teams.
• Strong analytical and strategic thinking skills with the ability to assess research proposals for scientific merit and alignment.
• Excellent communication, interpersonal, and presentation skills to engage…