Scientist II, Drug Product

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC‑6236), a RAS(ON) multi‑selective inhibitor; elironrasib (RMC‑6291), a RAS(ON) G12C‑selective inhibitor; zoldonrasib (RMC‑9805), a RAS(ON) G12D‑selective inhibitor; and RMC‑5127, a RAS(ON) G12V‑selective inhibitor, are currently in clinical development.

As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

Revolution Medicines is seeking a Scientist II to join the Drug Product team within Pharmaceutical Development & Manufacturing (PDM). This role will support the development of solid oral dosage forms for small molecule programs across the RVMD pipeline.

• Contribute to drug product development activities for new chemical entities (NCEs) from early development through late‑stage clinical development, with exposure to commercialization activities.
• Design and execute drug product development and manufacturing activities for solid oral dosage forms, including:
  • Preformulation and formulation development.
  • Manufacturing process development.
  • Process scale‑up, technology transfer, and process optimization.
  • Process validation and commercial manufacturing support.
• Support outsourced development and GMP drug product manufacturing activities at CDMOs including manufacturing oversight and troubleshooting.
• Design and execute experiments, analyze and interpret data and present results and conclusions to project teams.
• Work independently with limited supervision to conduct appropriate research and troubleshoot technical challenges, escalating complex issues as needed.
• Author and contribute to CMC documentation for regulatory submissions (e.g., INDs, NDAs, MAAs) and internal technical reports.
• Collaborate cross‑functionally within the CMC team (Clinical Supply, Analytical Development/QC, Quality Assurance, Drug Substance, Regulatory Affairs, and Project Management) and at enterprise level research/clinical/commercial teams to support aligned development strategy and execution.
• Travel up to 20 % to CRO/CDMO sites to support and oversee development and manufacturing operations.

• A degree in Pharmaceutical Science, Chemistry, Chemical Engineering, or a closely related field is desirable.
• Ph.D. with a minimum of 3 years of experience or a bachelor’s/master’s degree with appropriate experience in the pharmaceutical/biotech industry settings.
• Experience supporting drug product development and manufacturing for small molecules.
• Demonstrated experience in solid oral dosage formulation and process development for small molecules.
• Experience working with external partners (CDMOs/CROs) and overseeing outsourced development and manufacturing activities.
• Working knowledge of global regulatory expectations, including ICH guidelines and FDA, EMA, PMDA etc. requirements.
• Experience contributing to CMC regulatory filings is desirable.
• Strong technical writing, communication, and problem‑solving skills.
• Ability to manage multiple priorities and thrive in a fast‑paced, innovation‑driven collaborative environment.

• Ph.D. degree in Pharmaceutical Science, Chemistry, Chemical Engineering, or a closely related field is desirable.

The base pay salary range for this full‑time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location.

Individual base pay salary is determined by multiple factors, including job‑related skills, experience, market dynamics, and relevant education or training.

$132,000 – $166,000 USD

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.