Principal Product Manager, Chemistry

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

We are seeking a Principal Product Manager, Chemistry to deliver products and capabilities that help Chemistry teams make faster, higher-confidence design and progression decisions in oncology-focused drug discovery.

This role will define and deliver the product strategy for Chemistry workflows, data products, and AI-enabled decision support using the right mix of internal product development, SaaS platforms, vendor partnerships, integrations, and Rev Core capabilities. You will partner with medicinal chemists, synthetic chemists, computational chemists, analytical chemists, DMPK and Biology partners, Data Science, ML Engineering, Data Engineering, IT, and platform teams to turn complex Chemistry workflows into intuitive, scalable solutions that accelerate the Design-Make-Test-Learn cycle.

• Define the vision and roadmap for Chemistry products and capabilities across medicinal chemistry, synthetic chemistry, analytical chemistry, compound management, and the Design-Make-Test-Learn cycle.
• Build a Now, Next, Later roadmap from foundational compound data capabilities to self-service analytics, model-supported design, and AI-enabled decision support.
• Set success metrics tied to trusted compound data access, reduced manual data preparation, faster design cycles, compound progression decisions, and scientific adoption.

• Understand workflows for medicinal chemists, synthetic chemists, computational chemists, analytical chemists, compound management teams, and cross-functional program teams.
• Design solutions around key decision moments such as compound design, analog selection, route selection, synthesis planning, SAR interpretation, multi-parameter optimization, compound triage, and program prioritization.
• Translate Chemistry workflows into clear product requirements, evaluation criteria, user stories, and prioritized capabilities.
• Determine when to build, buy, partner, or integrate based on user needs, market capabilities, scalability, differentiation, interoperability, and long-term maintainability.

• Partner with technical teams, vendors, and SaaS providers to deliver priority Chemistry capabilities across Rev Core and core Chemistry platforms.
• Clarify trusted sources and systems of record for key Chemistry data, including compounds, structures, batches, lots, reactions, routes, analytical results, assay results, and calculated properties.
• Improve structured data capture, data quality, metadata, and usability across Benchling, D360, legacy CDD data, compound registration, analytical systems, inventory systems, and related Chemistry platforms.

• Enable self-service access, compound search, structure search, SAR exploration, semantic discovery, and “Ask your Chemistry data” experiences…