Computational Imaging Postdoctoral Fellow; Cryo-EM

Computational Imaging Postdoctoral Fellow (Cryo-EM)

Berkeley Lab’s ( LBNL ) Molecular Biophysics and Integrated Bioimaging ( MBIB ) is looking for a Postdoctoral Fellow to work on the development of computational methods and software for protein structure determination.

In this exciting role, you will develop new mathematical approaches and computational algorithms to investigate protein structure and conformational heterogeneity from cryo-electron microscopy (cryo-EM) datasets, including single-particle imaging and in-situ cellular tomography. This research will focus on developing hybrid approaches that integrate deep generative models with classical optimization techniques, numerical linear algebra, and Fourier analysis. The key objectives include advancing optimization algorithms for the refinement of single-particle and subtomogram data to achieve improved structural resolution and interpretability.

This position involves implementing and validating methods using both simulated and experimental datasets, organizing and presenting results to collaborators and the broader scientific community, and preparing manuscripts for publication in peer‑reviewed journals.

The anticipated start date for this position is June 1, 2026, though an earlier start may be possible.

We’re here for the same mission, to bring science solutions to the world. Join our team and YOU will play a supporting role in our goal to address global challenges! Have a high level of impact and work for an organization associated with 17 Nobel Prizes!

We invest in our employees by offering a total rewards package you can count on:

• Exceptional health and retirement benefits, including pension or 401K‑style plans
• A culture where you’ll belong – we are invested in our teams!
• In addition to accruing vacation and sick time, we also have a Winter Holiday Shutdown every year.
• Parental bonding leave (for both mothers and fathers)

What You Will Do:

• Develop and implement advanced computational algorithms for protein structure determination using cryo‑electron microscopy including:
  • Generative modeling of conformational heterogeneity in electron microscopy.
  • Data‑driven methods that use machine learning for reconstructing non‑rigid structural variability.
  • Algorithms for automated alignment of single‑particle and/or electron tomography data
  • theory and optimization techniques for tackling noise, missing data, and completion of models.
  • Automated pipelines for data analysis, structure completion, and model validation.
• Apply these methods to obtain high‑resolution three‑dimensional reconstructions of biomolecular structures from single‑particle and cellular tomography data.
• Disseminate research outcomes through publications in high‑impact, peer‑reviewed journals and presentations at seminars, workshops, and international conferences.
• Maintain clear and well‑organized documentation of theoretical developments, mathematical derivations, software implementations, and results.
• Contribute to the preparation of results, figures, and write‑ups for research and grant proposals.

What is

Required:

• A recent Ph.D. (within the last 1‑2 years) in Computational Biophysics/Physics, Computational Cryo‑Electron Microscopy, Applied Mathematics, Computer Science, or a closely related discipline.
• A solid background in Cryo‑Electron Microscopy, with an emphasis on reconstruction workflows.
• Experience developing numerical methods for solving inverse problems in imaging including iterative reconstruction techniques, regularization methods, and uncertainty‑aware modeling.
• Experience with generative models, variational inference, and physics‑informed machine learning approaches.
• Experience coding in Python and PyTorch.
• Knowledge of numerical linear algebra, optimization techniques, and Fourier analysis as applied to imaging and inverse problems.
• Proven ability to design, implement, and evaluate computational algorithms for complex scientific problems.
• Strong organizational skills including experience maintaining detailed and accurate records of experiment results and analyzed data.
• Excellent oral and written communication skills including experience organizing/presenting technical reports and a…