Bioinformatics Programmer

Job Description

A cover letter is required for this role. The Kidney Genetics, Genomics, and Advanced Models Laboratory at the UCSF Mission Bay campus is recruiting an individual with expertise in computational biology.

• Independent analysis of single cell and bulk genomics data including from CRISPR screens, kidney organoid models, and primary cell models. Datasets generated and used by the laboratory include single cell and bulk RNA‑seq, single cell and bulk ATAC‑sequencing, ChiP‑sequencing, and HiC.
• Analysis of biobank scale human genetics data to identify novel genotype‑phenotype and gene‑environment interactions.
• Figure generation and writing for publications and grant proposals.
• Coordination and management of laboratory compute resources.

Candidates will be expected to work independently and in a collaborative multidisciplinary team. Opportunities for career development will be provided and encouraged. The candidate will report to Gabriel Loeb, MD, PhD, the Principal Investigator of the Kidney Genetics, Genomics, and Advanced Models Laboratory.

• Bachelor’s degree in Bioinformatics/Systems Biology/Math/Statistics/Computer/Computational/Data Science, or Domain Sciences with computer/computational/data specialization or equivalent experience/training.
• 3 or more years of directly relevant programming experience.
• Proficiency in at least one programming language used for single-cell analysis (e.g., R or Python), including use of established single-cell analysis frameworks.
• Thorough knowledge of bioinformatics methods, applications programming, web development and data structures.
• Thorough knowledge of bioinformatics programming design, modification and implementation.
• Independently design and execute end-to-end single-cell analysis pipelines.
• Strong project management skills.
• Ability to generate publication‑quality figures and clearly communicate analytical results in writing.
• Demonstrated ability to work independently and collaboratively within a multidisciplinary research team.
• Make and defend methodological choices for normalization, integration, and statistical testing.
• Partner closely with experimentalists to shape data generation and interpret biological findings.
• Thorough knowledge of modern biology and applicable field of research.
• Communication skills to work with both technical and non‑technical personnel at various levels in the organization.
• Ability to communicate technical information in a clear and concise manner.
• Ability to interface with management on a regular basis.
• Self‑motivated, work independently or as part of a team, able to learn quickly, meet deadlines and demonstrate problem‑solving skills.
• Thorough knowledge of web, application and data security concepts and methods.

• PhD degree in Bioinformatics/Systems Biology/Math/Statistics/Computer/Computational/Data Science, or Domain Sciences with computer/computational/data specialization or equivalent experience. Strong preference for those with experience in advanced single‑cell sequencing and genome‑wide association data analyses. Substantial experience with single‑cell data integration, batch correction, and multi‑modal analysis.
• Experience analyzing perturbation-based single‑cell datasets, including CRISPR or pooled screens.
• Experience working with organoid or disease‑model single‑cell datasets.
• Familiarity with scalable or high‑performance computing environments for large single‑cell datasets.
• Experience with bulk genomics and human genetics data.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

The final salary and offer components are subject to additional approvals based on UC policy. Your placement within the salary range is dependent on a number of factors including your work experience and internal equity within this position classification  positions that are represented by a labor union, placement within the salary range will be guided by the rules in the collective bargaining agreement.

To learn more about the benefits of working at UCSF, including total compensation, please visit (Use the "Apply for this Job" box below)..html