Scientist​/Senior Scientist, Metabolomics Group Lead

Scientist / Senior Scientist, Metabolomics Group Lead

The Mass Spectrometry Hub sits within the Institute of Technology, where we have access to an array of cutting‑edge instrumentation. Together we are a team with a wide variety of skills and experiences that tackle exciting challenges across all of Altos. The Scientist / Senior Scientist, Metabolomics Group Lead is responsible for end‑to‑end management of metabolomics and lipidomics projects, from experimental design through sample preparation, measurement, data processing and data delivery.

This role partners cross‑functionally with scientific and bioinformatics teams to ensure robust, reproducible data generation, maintain operational excellence of LC‑MS platforms, and drive projects to successful and timely completion.

• Collaborate with cross‑functional scientists to define project objectives, assess feasibility, and establish clear deliverables and timelines.
• Execute and supervise sample preparation workflows for steady‑state metabolomics and lipidomics.
• Operate, maintain, and troubleshoot LC‑MS instrumentation (e.g., Thermo Exploris 240, SCIEX 7500, Vanquish HPLC) to ensure optimal performance and minimal downtime.
• Optimize and adapt extraction protocols to support analysis of diverse and challenging biological samples.
• Process and analyze raw datasets with software (e.g., Skyline, Compound Discoverer), and coordinate with bioinformatics teams to ensure accurate data processing, quality control, and efficient project execution.
• Maintain accurate and up‑to‑date project tracking and documentation in systems, such as Benchling, and shared project management tools.
• Communicate project status, timelines, and risks effectively to internal stakeholders and leadership.

• PhD (or equivalent experience) in metabolomics, lipidomics, analytical chemistry, biochemistry, or a related discipline.
• More than 6 years of hands‑on experience with both HRAM and LRMS, preferably with Orbitrap Exploris and SCIEX triple quadrupole mass spectrometry platforms.
• Strong experimental design and problem‑solving skills, with experience performing sample preparation of cells, tissues, and biofluids.
• Demonstrated experience with mentoring and project management, including managing collaborations with scientists with diverse training backgrounds.

• Experience developing new methods for analysis of metabolites/lipids of interest.
• Prior experience in metabolite identification and trapping in the context of drug metabolism.
• Experience performing large‑scale discovery studies of more than 1,000 samples.
• Experience designing and interpreting complex isotope tracing experiments (e.g., metabolic flux analysis).
• Experience integrating metabolomics/lipidomics with other omics, including proteomics and transcriptomics.

Location:

Redwood City, California (on‑site).

Scientist II: $156,800 – $201,000

Senior Scientist: $172,400 – $221,000

Altos Labs provides equal employment opportunities to all employees and applicants for employment, without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. Altos prohibits unlawful discrimination and harassment. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.