Bioinformatics Engineer - RefusalBench

About the Role

At Latch Bio, we build the benchmarks that frontier AI labs use to evaluate and train models on biological reasoning. Refusal Bench tests whether AI systems can distinguish legitimate biological research from requests that present meaningful biosecurity risks.

We're looking for scientists with deep expertise in areas such as biosecurity, biosafety, pathogen genomics, infectious disease research, synthetic biology, biodefense, and public health. Your role will be to apply that expertise to determine where the boundary lies between routine scientific work and potentially dangerous biological capabilities.

You will review real-world biological analyses, protocols, datasets, and research papers to establish ground truth for AI evaluations. Some tasks should clearly be allowed. Others should clearly be refused. Many sit in the gray area. Your job is to identify the relevant risks, justify the correct decision, and convert those examples into structured evaluations that test whether AI systems reach the same conclusion.

• Review biological tasks, datasets, protocols, and research workflows to determine whether they should be accepted or refused from a biosecurity perspective
• Identify the specific risk categories involved, including pathogen engineering, immune evasion, enhanced transmissibility, countermeasure resistance, and other dual‑use concern
• Source real‑world examples from the scientific literature and convert them into evaluation tasks with clear ground truth and supporting rationale
• Document the reasoning and evidence supporting each decision so that evaluations are scientifically defensible and consistently graded
• Review agent outputs to determine whether models correctly identify risks, over‑refuse legitimate research, or fail to recognize dangerous capabilities
• Help build a high‑quality corpus of biosecurity evaluations grounded in real biological research and real‑world risk assessment

• Biosecurity & biodefense programs
• Biosafety and risk assessment organizations
• Public health agencies (CDC, WHO, state health departments)
• Pathogen genomics and molecular epidemiology groups
• Synthetic biology and biotechnology governance
• Pandemic preparedness and emerging infectious disease programs
• Infectious disease surveillance and outbreak response

• Salary: $120k–$180k (base + performance pay that scales with output)
• Produce 50 evals/week at baseline — exceed that and performance pay scales linearly
• Fast‑track promotion for strong performers
• Fully remote or onsite
• Equity
• Unlimited PTO
• Visa sponsorship available

• Intro call with Saúl (Technical Recruiter)
• Technical interview with Harmon (Pod Lead)
• Cultural interview with Jordan (Chief of Staff)
• Offer

San Francisco, CA. In‑person.