Principal Scientist, Immunology

Key Responsibilities

• Design and lead in vitro and in vivo studies to uncover mechanisms driving inflammatory and autoimmune diseases.
• Discover and validate novel drug targets, biomarkers, and pathways for immune‑mediated disorders.
• Deliver high‑quality data supporting lead optimization, biomarker development, and translational research.
• Analyze/interpret complex datasets with scientific rigor, reproducibility, and adherence to regulatory/safety standards; present internally and externally.
• Collaborate across disciplines (pharmacology, synthetic medicine, protein engineering, computational sciences) to advance target identification, drug discovery, and clinical development.
• Shape portfolio strategy by identifying scientific gaps and innovation opportunities.
• Partner with business development/corporate strategy to evaluate scientific merit of assets, collaborations, and licensing.
• Support due diligence (mechanistic evaluations, protocol reviews, external data assessment, IP analysis).
• Stay current on emerging immunology/inflammation research and technologies.

• PhD in Immunology/Cellular & Molecular Biology or related field + 5+ years industry experience (MS 8+, BS 10+), preferably in inflammatory/autoimmune drug discovery and development.
• Expertise in immune cell biology (innate/adaptive), cell signaling, and immunological assay development.
• Hands‑on experience with biochemical/cellular assay development, tissue culture, flow cytometry, and functional genomics.
• Experience with inflammation and/or autoimmunity disease models.
• Ability to manage multiple priorities; strong problem‑solving; works independently and in teams.
• Analytical and communication skills to translate complex science into business‑relevant insights.

• 5+ years biotech/pharma drug discovery or translational research.
• Experience with small molecules, biologics, and/or cell‑based therapeutics.
• Multiparametric flow cytometry (e.g., 15+ colors); multiomics experience.
• Due diligence/business development support experience (highly desirable).

Onsite in South San Francisco, CA; frequent onsite presence; must be within commuting distance or able to self‑relocate.

Base $142,000–$190,000; eligibility for short‑ and long‑term incentives. Medical/Dental/Vision/Life, fitness reimbursement, disability, paid vacation + shutdown, holidays, sick time, paid maternity/parental leave, 401(k) match, stock purchase plan, tuition reimbursement up to $10,000/year, Employee Resource Groups participation.